Protein Info for DvMF_0487 in Desulfovibrio vulgaris Miyazaki F

Annotation: ribose-phosphate pyrophosphokinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 PF13793: Pribosyltran_N" amino acids 5 to 121 (117 residues), 171.9 bits, see alignment E=6e-55 TIGR01251: ribose-phosphate diphosphokinase" amino acids 6 to 311 (306 residues), 403.9 bits, see alignment E=1.9e-125 PF00156: Pribosyltran" amino acids 162 to 248 (87 residues), 66.6 bits, see alignment E=2.4e-22 PF14572: Pribosyl_synth" amino acids 198 to 311 (114 residues), 95.7 bits, see alignment E=5e-31

Best Hits

Swiss-Prot: 63% identical to KPRS_DESPS: Ribose-phosphate pyrophosphokinase (prs) from Desulfotalea psychrophila (strain LSv54 / DSM 12343)

KEGG orthology group: K00948, ribose-phosphate pyrophosphokinase [EC: 2.7.6.1] (inferred from 100% identity to dvm:DvMF_0487)

MetaCyc: 53% identical to ribose-phosphate diphosphokinase (Escherichia coli K-12 substr. MG1655)
Ribose-phosphate diphosphokinase. [EC: 2.7.6.1]

Predicted SEED Role

"Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)" in subsystem De Novo Purine Biosynthesis or Pentose phosphate pathway (EC 2.7.6.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DKL5 at UniProt or InterPro

Protein Sequence (312 amino acids)

>DvMF_0487 ribose-phosphate pyrophosphokinase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MHGDLKILTGTSNPALAKAICNHLGCQLTPALCETFSDGEIRIEIGDNVRGDDVFVVQAT
CSPVNYNLMQLCLMLDALKRASAGRVTAVVPYYGYARQDRKVSPRAPISAKLVADFLTTA
GTDRVVTVDLHAGQIQGFFNVPVDNLYAQPVILEYLRPYAGDIVIVSPDAGGVERARSFA
KKLNAGLAIIDKRRDRPNQASAMHVIGDVRDKIAIVVDDMIDTAGTMCAAGEVLLKNGAK
EVMACATHPVLSGPAIERLCNSTFSQVIVTDTVPLGDKLAACSKLKVLSVAGLLAKAIHN
IHTESSVSVLFV