Protein Info for DvMF_0465 in Desulfovibrio vulgaris Miyazaki F

Annotation: response regulator receiver modulated CheB methylesterase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 PF00072: Response_reg" amino acids 8 to 110 (103 residues), 72.2 bits, see alignment E=3.9e-24 PF01339: CheB_methylest" amino acids 174 to 352 (179 residues), 224 bits, see alignment E=1.1e-70

Best Hits

Swiss-Prot: 78% identical to CHEB2_DESAG: Protein-glutamate methylesterase/protein-glutamine glutaminase 2 (cheB2) from Desulfovibrio alaskensis (strain G20)

KEGG orthology group: K03412, two-component system, chemotaxis family, response regulator CheB [EC: 3.1.1.61] (inferred from 100% identity to dvm:DvMF_0465)

Predicted SEED Role

"Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61)" in subsystem Bacterial Chemotaxis (EC 3.1.1.61)

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.61

Use Curated BLAST to search for 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DJV0 at UniProt or InterPro

Protein Sequence (356 amino acids)

>DvMF_0465 response regulator receiver modulated CheB methylesterase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTPRRIKVLVVDDSALVRQTLADIVAGDEELELIGTASDPFVAAKRMETVAPDVILLDVE
MPRMDGITFLRKIMTQHPIPVVICSSVTEQGAEATFKAMEYGAVEVIQKPRMGTKRFLEE
SSIRICDALKAAARARLRKLSPLAAGVPPKLSADAVLPAATPLTTTVQQTEKVVVIGAST
GGTEALRVVLEALPADCPPIAIVQHMPEHFTAAFANRLNAICRVAVKEAQDNDAMRRGQV
LIAPGNMHMLLKRNGSRYYVEVREGPLVRRHRPSVDVLFRSAARYAGRNAVAAIMTGMGD
DGAAGMKELFDVGAHTIAQDEASCVVFGMPQEAIKLGGVRKVVSLEEIAPAIIRAC