Protein Info for DvMF_0433 in Desulfovibrio vulgaris Miyazaki F

Name: pyrG
Annotation: CTP synthetase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 538 (537 residues), 814.8 bits, E=1.5e-249
• PF06418: CTP_synth_N
  • amino acids 4 to 266 (263 residues), 423.1 bits, E=6.4e-131
• PF00117: GATase
  • amino acids 303 to 537 (235 residues), 143.3 bits, E=1.1e-45
• PF07722: Peptidase_C26
  • amino acids 366 to 520 (155 residues), 26.2 bits, E=9.5e-10

Best Hits

Swiss-Prot: 100% identical to PYRG_DESVM: CTP synthase (pyrG) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 100% identity to dvm:DvMF_0433)

MetaCyc: 57% identical to CTP synthetase (Escherichia coli K-12 substr. MG1655)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• L-glutamate and L-glutamine biosynthesis (4/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)
• superpathway of pyrimidine ribonucleosides salvage (6/10 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Sequence Analysis Tools

See B8DJR8 at UniProt or InterPro

Protein Sequence (550 amino acids)

>DvMF_0433 CTP synthetase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MKTKFIFITGGVLSSLGKGLAAASIGALLKARGLKVTIQKLDPYINVDPGTMNPFQHGEV
YVTDDGAETDLDLGHYERYLGESLSQKNNYTSGSIYNRVITKERRGDYLGGTVQVIPHVT
DEIKNAILGLAEDEPDVALIEIGGTVGDIEGLPFLEAIRQLRGDLGKDHCLYVHLTLVPY
LKAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAISAELKRKIALFCDVDQDAVFSSV
DVDNIYEVPLRFYEEGFDQKIAIMLRLPAKNANLESWETLIHTCSHPEGQVTIGIVGKYV
DLKEAYKSLHEALIHGGVANKVKVNLRYVNSEEITEANVAEKLAGCDGILVPGGFGHRGV
EGKIRSIRHAREHKIPFFGICLGMQCAVIEYARNVLGLADANSEEFNELTDNKVIYLMTE
WYDFRKGAVERRDASSDKGGTLRLGAYPCVVVPGTRAWDAYGAERVDERHRHRFEFNKAY
FEAMAEKGLVFSGLSPDGELVEIVELPDHPWFLGCQFHPEFKSNPMRPHPLFREFIKAAK
KEAMGGKKGK