Protein Info for DvMF_0361 in Desulfovibrio vulgaris Miyazaki F
Annotation: LL-diaminopimelate aminotransferase (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to DAPAT_DESVM: LL-diaminopimelate aminotransferase (dapL) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
KEGG orthology group: K10206, LL-diaminopimelate aminotransferase [EC: 2.6.1.83] (inferred from 100% identity to dvm:DvMF_0361)MetaCyc: 39% identical to glutamate--pyruvate aminotransferase AlaC (Escherichia coli K-12 substr. MG1655)
Alanine transaminase. [EC: 2.6.1.2]
Predicted SEED Role
"L,L-diaminopimelate aminotransferase (EC 2.6.1.83)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.6.1.83)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- L-lysine biosynthesis VI (7/7 steps found)
- L-alanine degradation V (oxidative Stickland reaction) (2/2 steps found)
- L-alanine biosynthesis II (1/1 steps found)
- L-alanine degradation III (1/1 steps found)
- superpathway of L-alanine biosynthesis (3/4 steps found)
- L-alanine degradation II (to D-lactate) (2/3 steps found)
- pyruvate fermentation to acetate and alanine (2/3 steps found)
- anaerobic energy metabolism (invertebrates, cytosol) (4/7 steps found)
- superpathway of L-alanine fermentation (Stickland reaction) (4/9 steps found)
- L-alanine degradation VI (reductive Stickland reaction) (1/6 steps found)
- C4 photosynthetic carbon assimilation cycle, NAD-ME type (4/11 steps found)
- C4 photosynthetic carbon assimilation cycle, PEPCK type (6/14 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (7/17 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Carbon fixation in photosynthetic organisms
- Glutamate metabolism
- Lysine biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.2 or 2.6.1.83
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B8DJJ6 at UniProt or InterPro
Protein Sequence (389 amino acids)
>DvMF_0361 LL-diaminopimelate aminotransferase (RefSeq) (Desulfovibrio vulgaris Miyazaki F) MADFKLADRLATLPPYLFAGIDKVKAEVAARGVDIISLGIGDPDMPTPDFIIEAMKKAVE RPANHQYPSYVGMLEFRQEVANWYGRRFGVSLDPKTEVIGLIGSKEGIAHFPLAFVNPGD LVLVCTPNYPVYHIATGFVGGEVQFIPLVEENDYLPDLDAIPAATWDRAKMIFVNYPNNP TAATAPRAFYEKLIGICRKHNVIIAHDTAYTEVYYDENDKPMSILEVEGAKDVTIEFHSL SKTYNMTGWRVGMAVGNASLVAGLGKVKENVDSGIFQAVQEASIVALRDGDDFCRELRGI YRKRRDVVVAALNKVGIACRVPTAAFYIWAKVPAGYGSSAEFVTAVLEKTGVVLTPGNGF GTPGEGYFRISLTVDTDRLEEAVSRIANL