Protein Info for DvMF_0355 in Desulfovibrio vulgaris Miyazaki F

Annotation: DNA mismatch repair protein MutS (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 910 PF01624: MutS_I" amino acids 1 to 110 (110 residues), 140.4 bits, see alignment E=7.1e-45 TIGR01070: DNA mismatch repair protein MutS" amino acids 1 to 884 (884 residues), 923.5 bits, see alignment E=6.9e-282 PF05188: MutS_II" amino acids 119 to 247 (129 residues), 55.1 bits, see alignment E=2.9e-18 PF05192: MutS_III" amino acids 265 to 572 (308 residues), 140.5 bits, see alignment E=2.3e-44 PF05190: MutS_IV" amino acids 441 to 531 (91 residues), 91.9 bits, see alignment E=6.2e-30 PF00488: MutS_V" amino acids 624 to 813 (190 residues), 271.1 bits, see alignment E=1.4e-84

Best Hits

Swiss-Prot: 77% identical to MUTS_DESVV: DNA mismatch repair protein MutS (mutS) from Desulfovibrio vulgaris subsp. vulgaris (strain DP4)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 100% identity to dvm:DvMF_0355)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DJJ0 at UniProt or InterPro

Protein Sequence (910 amino acids)

>DvMF_0355 DNA mismatch repair protein MutS (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MFEQYLRIKDDYPDALLLYRMGDFYEMFFDDAETAARELQIALTCRNPNADLRVPMCGVP
HHSVEGYITQLLEKGFKVALCDQIEDPREAKGLVKRAVTRVLTPGTVVEDANLDAKGHNY
LGALFWDEEKEAGGFAWLDFSTGEWSGLHAKKAADLWQWVRKMQPRELLVTESAQVPSSM
SLTSTQVVRVPGRAPFDLKAATERLLHAQGVRDTGALGLEGKDELVRSCGALLAYVVQTQ
KQDIIHLAPFRPLNLGRHLIVDEVTERNLEIFRRLDGRKGPGTLWHVLDHTQTPMGGRLL
EERLRHPWREMGPIEETQAAVSWLFERDDTRRDLRAGLDEVYDLERLTTRIFLNRAAPKD
YVALRQSLAALPKVRGVLERTETPHGGYPTDGEARGDGRPPFLRAALKGWDDLSDYFDLL
ERALVDSPPHLVTEGGLFRPGFHAELDELLDLTEHGENMLQQLLAEEQAASGLPRLKLGF
NRVFGYYFELSRTASDAVPEHFVRRQTLANAERFTTPRLKELEEKLVSASDRRKSLEYKL
FQKLRETVSEARPRVLFMADLLAGFDYWQSLAETARRWNWTRPVLAQDADILIREGRHPV
VEAMQGSANFIPNDLRMDEARRLLLITGPNMAGKSTVLRQTAIICLLAQMGSFVPAREAR
LGIADRVFSRVGASDNLAQGQSTFMVEMMETARILRQAGKRSLVILDEIGRGTSTFDGLA
LAWAVVEELARRAGGTIRTLFATHYHELTALEGRIPGVHNMNIAIREWGGEIVFLRRLVP
GPSDRSYGIEVARLAGVPQPVVQRARELLHELEKARDGRGEAPRTARAVLPGLDMPEPKQ
AAKPRALLAARAEPVAHPLLTTLRDLDTDHLTPMGALQLLNEWKLLWGGPAHAEDTVPDQ
PPAAPGDDRD