Protein Info for DvMF_0207 in Desulfovibrio vulgaris Miyazaki F
Annotation: thiamine biosynthesis protein ThiC (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 52% identical to THIC_DESOH: Phosphomethylpyrimidine synthase (thiC) from Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
KEGG orthology group: K03147, thiamine biosynthesis protein ThiC (inferred from 100% identity to dvm:DvMF_0207)MetaCyc: 46% identical to 5-hydroxybenzimidazole synthase BzaB subunit (Moorella thermoacetica)
RXN-17122 [EC: 4.1.99.23]
Predicted SEED Role
No annotation
MetaCyc Pathways
- adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
- 5-hydroxybenzimidazole biosynthesis (anaerobic) (1/1 steps found)
- 5-methoxybenzimidazole biosynthesis (anaerobic) (1/2 steps found)
- 5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic) (1/3 steps found)
- 5,6-dimethylbenzimidazole biosynthesis II (anaerobic) (1/4 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.99.23
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B8DNW0 at UniProt or InterPro
Protein Sequence (429 amino acids)
>DvMF_0207 thiamine biosynthesis protein ThiC (RefSeq) (Desulfovibrio vulgaris Miyazaki F) MSILTRNTALAGVLDTHLAALAADEGLAPQTIRDGIEGGTMVLLGNPSHPSLRPLLVGQP SRVKVNANIGTSPLCNNPDREIEKLAAALAAGADTVMDLSIAGDLLAIRKGMLAACPLPL GTVPLYSVAQKYLDKGKDPAGMDPEELFAEIEMQAEQGVDFMTVHCGLTRRGAEWATEGG RVLGIVSRGGSILARWMRKNGKETPLLEQYDRILEIARRHNVTLSLGDGLRPGAGADAGD AAQWEEVMMLGRLAKAGLAEGVQCMIEGPGHVPMHEVEAQIVGIKKLTNNAPLYVLGPLT IDSSPGYDHIAGAIGGAIGVRAGVDFLCYLTPAEHLTLPTIEDVKAGVMASRIAAQAGEV ALGRRHALEREAGMSQARMALDWDGMKRCALDPEMVDARRGEHRNEEECAMCGKFCAVKM LRDDPQGTL