Protein Info for DvMF_0130 in Desulfovibrio vulgaris Miyazaki F

Annotation: DNA polymerase III, alpha subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1173 TIGR00594: DNA polymerase III, alpha subunit" amino acids 4 to 1025 (1022 residues), 1356.9 bits, see alignment E=0 PF02811: PHP" amino acids 6 to 175 (170 residues), 192.6 bits, see alignment E=1.5e-60 PF07733: DNA_pol3_alpha" amino acids 295 to 558 (264 residues), 346 bits, see alignment E=4e-107 PF17657: DNA_pol3_finger" amino acids 561 to 726 (166 residues), 210.1 bits, see alignment E=3.5e-66 PF14579: HHH_6" amino acids 799 to 886 (88 residues), 96.1 bits, see alignment 2.9e-31 PF01336: tRNA_anti-codon" amino acids 993 to 1053 (61 residues), 27.8 bits, see alignment 5.1e-10

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 100% identity to dvm:DvMF_0130)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DNN4 at UniProt or InterPro

Protein Sequence (1173 amino acids)

>DvMF_0130 DNA polymerase III, alpha subunit (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MSDFVHLHCHTEYSLLDGAIRLKDLCAKAVDFGMPAAAITDHGNLYGAVYFYNTCKQFGI
KPIIGCEVYVANDHTDKTSELARVRHHLVLLARDNEGYHNLVKLVSHGFLHGFHYKPRVD
MDLLRQYSGGITALSACLAGQVPRALLRSGMDDAIRIAREYEAIYPGNFYLELQSNGLKE
QDELNEKLIELADHTGLPLVATNDCHYLEASDVEAHDVLLCIQTQAKVDDERRMRFETKE
LYYKSPEEMAKAFAHVPDAVANTGRIAEQCAVKFEFGKYVFPVYALPEGMTLEDEFRRLS
REGLKRRLERHPNRDTIDHDLYWKRLELELDVIGQMGFPGYFLIVQDFINWAKDNGIPVG
PGRGSAAGSLVAWSLRITNLDPIPYNLLFERFLNIERVSMPDIDVDFCERRRTEVIRYVG
EKYGEDMVAQITTFGKMKAKAVVRDVGRALGMTFAETDRIAKLVPEDLKMTVKKAIDAEP
DLAALYKTDPQIRKLLDVSMRLEGLSRHASTHAAGVVVSDRPMREYLPLYRGKKGEIVTQ
FDMKMVEKVGLVKFDFLGLRTMTLVQDSLDEIARQGKTPPDLDTLALDDAETYELYSRGD
TDGIFQVESSGMRQYLRMLKPSCFDDVIAMLALYRPGPLGSGMVDEFIKRKHGEVPVTYP
LPSLEDCLRDTYGVIVYQEQVMQIAQIAAGYTLGGADLLRRAMGKKNAEEMGQQRIKFVE
GAQKNGVPKATADEIFDLMEKFAEYGFNKSHSAAYALISYYTAYLKVHFPTEFMAALLTS
EMGNQDKLLKYVAACKDMGIAVLQPNVQASRREFTVHEGAIVFGLGGIKNVGDEAIREIV
DAREEGGVFASLLDLCMRVNLRKVTKRVLESLIKGGACDCLGCTRAGMLAALDNVVSKAQ
KRLKDKESNQVSLFTMVPEEPAVCPGIGFDCEEQQAQEWDDDQKLRFEKEALGFFLTSHP
LQPYRKELFRLRLTPLEETRDMAPGMSLKTAVLVTGIKEHMTKKGARMAFLQVEDLTASG
ECVFFPEPYAEFRELLKSDQPLLLEATISKQQNDDGGRNGGGGDGMSGSAGMTEDDDDTP
REIKLLGDKVIPLARACGASDQPVTIDMPLPRVEPASLAALRAILERHRGPVPVNVRLVV
DESECLLQFGPQWMVQPGPAFETDIAHWTEGPE