Protein Info for Shewana3_4066 in Shewanella sp. ANA-3

Annotation: CzcA family heavy metal efflux protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1017 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 359 to 377 (19 residues), see Phobius details amino acids 389 to 412 (24 residues), see Phobius details amino acids 433 to 453 (21 residues), see Phobius details amino acids 465 to 492 (28 residues), see Phobius details amino acids 524 to 543 (20 residues), see Phobius details amino acids 858 to 877 (20 residues), see Phobius details amino acids 885 to 904 (20 residues), see Phobius details amino acids 913 to 934 (22 residues), see Phobius details amino acids 956 to 975 (20 residues), see Phobius details amino acids 987 to 1013 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1017 (1017 residues), 943.6 bits, see alignment E=6.8e-288 PF00873: ACR_tran" amino acids 6 to 1013 (1008 residues), 919.5 bits, see alignment E=1.3e-280

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to shn:Shewana3_4066)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L2L4 at UniProt or InterPro

Protein Sequence (1017 amino acids)

>Shewana3_4066 CzcA family heavy metal efflux protein (RefSeq) (Shewanella sp. ANA-3)
MLTSVIRFSLTQRLFVLIVALILMLAGARAWFAIPLDAFPDISPTQVKIILKAPGMTPEE
IEAQITVPIETELLGIPRQSILRSTTKYAISDITLDFEEGTDIYWARQQVSERLSAVWDS
FPEGVSGGVAPMSTPLSEIFMFSLENPNLSLLERRQLLEWEIRPLLRTVPGVADVNILGG
YAKSFSISPNPAAMSAAGVSFATLQQAIVENNHNEGAGKLTIGTDTIIVRSEGRIDDIDE
LKQLVIKADNAKVYRLQDLADVQIGHLARYGAVTKDGNETAEALIIALKDANTAQVVNNI
KEKLAQISLTLPEGSQINTFYDRANLINTAIETISNALFEAVVLVIVLLALFLGNVRAAL
VVSLSLPLAALFTFLMMDHFNLSANLMSLGGLVIAIGMLVDSSVVVVENMVNLIATKQRL
PRLHLIFRATKDVAIPVVSGTVIVIIVFSPLLTLSGLEGKLFTPVAITIVFAMLSALVLS
LTVIPVIASYLVNEKAAKEPKAVEKLKHLYLGSLKACFGWQKPFMLIAFSLLIISLGLFS
LVGKTFMPTLDEGDIILQLEKSPSISLDASIAIDKQIQQTLLIQIPEIKQMVARTGADEI
GLDPMGLNETDVFLELAPRSEWRFATKEQLIDAIRTVLLKYPGVNFNFTQPIQMRVSEML
TGSIGDVAIKVFGNDIETLGKLTGEIEQLVTATQGSVDVKMAMIEGSPFINLTLDNELAR
GFGMSTMEFARYLKSQLEGVVVTEVLQGKKRTPVLIANNQAQISNINELQNQLLVMPDHS
LKRLSDVAVLSYKQGPILIEREQGNRFSVITTNVQGRDIVGFVEELNSKIANEIKLPSGY
SVSFGGEFENQQRATSNLLLVIPIAIALITLILFTTFGSLAKSGLILANVPFAMMGGIVS
LYLSGEYLSVPASVGFIALLGVAVLNGVVMVSYYEQTKYLFGSLRERVEQGAARRLRPIL
MTATTAMFGLIPLVFASGPGAEIQKPLAIVVIGGLLTSTITTLYLLPMLYFWLEKRR