Protein Info for Shewana3_4015 in Shewanella sp. ANA-3

Annotation: response regulator receiver modulated diguanylate cyclase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 PF00072: Response_reg" amino acids 18 to 121 (104 residues), 97.9 bits, see alignment E=4e-32 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 142 to 307 (166 residues), 168.5 bits, see alignment E=5.2e-54 PF00990: GGDEF" amino acids 145 to 305 (161 residues), 158.7 bits, see alignment E=1.1e-50

Best Hits

KEGG orthology group: K02488, two-component system, cell cycle response regulator (inferred from 100% identity to shn:Shewana3_4015)

Predicted SEED Role

"Probable two-component response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L2G3 at UniProt or InterPro

Protein Sequence (315 amino acids)

>Shewana3_4015 response regulator receiver modulated diguanylate cyclase (RefSeq) (Shewanella sp. ANA-3)
MQYLSELMATQQATKGKILIVDDQPLNIKILHQLFHEEYEMFMATSGEQALQVCQKMQPD
LVLLDIEMPEMTGYEVCQRLKADPATANIGVIFITAHFDEMEEVKGFQLGAVDFIHKPIN
PIITSARVKNQYLLKRQSDVLHSIALLDSLTGVANRRQFEQRLPEIWRHCSRNQAYLSVI
MLDVDFFKRYNDRYGHQEGDQCLRLVADAVKGMLKRPNDLIARYGGEEFICILPEAKLSG
AMRLAQAMVDAVHALHLEHLDSEFGEVTVSAGIATIQPLAEQSWESLVEVADQQLYIAKH
NGRNQVVGIDIEPAQ