Protein Info for Shewana3_3163 in Shewanella sp. ANA-3

Annotation: sodium:dicarboxylate symporter (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 42 to 67 (26 residues), see Phobius details amino acids 79 to 101 (23 residues), see Phobius details amino acids 143 to 160 (18 residues), see Phobius details amino acids 184 to 202 (19 residues), see Phobius details amino acids 215 to 238 (24 residues), see Phobius details amino acids 254 to 271 (18 residues), see Phobius details amino acids 290 to 315 (26 residues), see Phobius details amino acids 323 to 341 (19 residues), see Phobius details amino acids 347 to 369 (23 residues), see Phobius details PF00375: SDF" amino acids 12 to 394 (383 residues), 434.5 bits, see alignment E=2e-134

Best Hits

Swiss-Prot: 40% identical to GLT_PYRHO: Glutamate transporter homolog (PH1295) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

KEGG orthology group: K06956, (no description) (inferred from 99% identity to she:Shewmr4_2983)

MetaCyc: 33% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"Sodium/glutamate symport protein" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L018 at UniProt or InterPro

Protein Sequence (417 amino acids)

>Shewana3_3163 sodium:dicarboxylate symporter (RefSeq) (Shewanella sp. ANA-3)
MILQTISRIPFWQKVLAGFILGALVGVLLGETATVLKPLGDLFISAIKMLVAPLVFCAIV
VSITSLGSQTNLKRLSLKTLGMFMLTGTVASLIGLAVGSLIDMGGTMQLATTEVRERNIP
GFAQVLLDMIPVNPFASLADGKVLQIIVFAALVGIAINKVGEKAEPLKRTIEAGAEVMFQ
LTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIAAIYIAALIHMIFVYGGLVKFAAG
LSPVQFFRKAMPAQLVAFSTSSSFGTLPASTRAVETMGVSKRYSAFVMPLGATMNMDGCG
GIYPAIAAIFIAQIYGIPLDTLDYVMIAVTATVASVGTAGVPGSAMVMLTVTLGVIGLPL
EGIAFIAAIDRIIDMIRTATNVTGDMMTAVVIGKSENELDVEQFYSNETQTAAIADN