Protein Info for Shewana3_2457 in Shewanella sp. ANA-3

Annotation: peptidase M1, membrane alanine aminopeptidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF17900: Peptidase_M1_N" amino acids 61 to 235 (175 residues), 70.5 bits, see alignment E=3.2e-23 PF01433: Peptidase_M1" amino acids 272 to 464 (193 residues), 156.1 bits, see alignment E=1.6e-49 PF09127: Leuk-A4-hydro_C" amino acids 522 to 630 (109 residues), 86.3 bits, see alignment E=2.3e-28

Best Hits

KEGG orthology group: None (inferred from 100% identity to shn:Shewana3_2457)

Predicted SEED Role

"Aminopeptidase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KY17 at UniProt or InterPro

Protein Sequence (642 amino acids)

>Shewana3_2457 peptidase M1, membrane alanine aminopeptidase (RefSeq) (Shewanella sp. ANA-3)
MFLSRRTLISSALLMLLPLVQYANAANTLPNTSLASSATSQMHSVTDELTFANYQQVSIH
HIELALNVDFAQQQISGDATLELDWHQAGKVLVLDTRDLTINSVSMLNANGQWQSVPFSL
GAADKVKGAALTINLPQERVAKVKVNYHTSKNPSGIQWLTPEQTQGKQWPFMFSQSQAIH
ARSWIPLQDTPAVRQTYSATVTAKQSISVVMSADRKSVSATQTQFTMPQAIPAYLIAIAA
GHLQFAALNDTSGIWAEPEMLAKASKEFADTPEMIAIAAKRYGDYRWGRYDLLILPPSFP
FGGMENPRLSFITPTVIAGDKSLVSLIAHELAHSWSGNLVTNATWRDLWLNEGFTTYVEN
RIMEDLYGRDRALMEQTIGYSELLAELAELPASDSVLHIDLGDRDPDDAFSGVPYVKGQL
FLRFLEQKFGRERFDTFVKSYFDHFAFQSITTEQFRSYLTQQLLQKYPNIVSESEVDTWV
EGQGLPSFLVPPNSHAFDDIDAQRQAWLEGKRAASSLNTQGWTVHQWLRFINEMPRLNLT
EQQLAELDKAFHFTGTHNNEIAFAWYALALDNGYYSVLPALKQHLTEIGRRRLIVPLYQK
LASSEHYDWAKTVYLAARSGYHPQTQASLDMMFSDKLMEHAH