Protein Info for Shewana3_1912 in Shewanella sp. ANA-3

Annotation: succinyl-diaminopimelate desuccinylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01246: succinyl-diaminopimelate desuccinylase
  • amino acids 10 to 379 (370 residues), 564.9 bits, E=3.7e-174
• PF01546: Peptidase_M20
  • amino acids 68 to 377 (310 residues), 146.8 bits, E=8.5e-47
• PF07687: M20_dimer
  • amino acids 181 to 288 (108 residues), 104.1 bits, E=3.9e-34

Best Hits

Swiss-Prot: 100% identical to DAPE_SHESA: Succinyl-diaminopimelate desuccinylase (dapE) from Shewanella sp. (strain ANA-3)

KEGG orthology group: K01439, succinyl-diaminopimelate desuccinylase [EC: 3.5.1.18] (inferred from 100% identity to she:Shewmr4_1857)

MetaCyc: 64% identical to succinyl-diaminopimelate desuccinylase (Escherichia coli K-12 substr. MG1655)
Succinyl-diaminopimelate desuccinylase. [EC: 3.5.1.18]

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate desuccinylase (EC 3.5.1.18)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 3.5.1.18)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.18

Sequence Analysis Tools

See A0KWH4 at UniProt or InterPro

Protein Sequence (381 amino acids)

>Shewana3_1912 succinyl-diaminopimelate desuccinylase (RefSeq) (Shewanella sp. ANA-3)
MTHASNTHPVTELTKELIARPSVTPLDEGCQTLMAERLAAIGFNIEPMVFEDTTNMWARR
GNEGPVFCFAGHTDVVPAGDLSRWHTPPFEPTIIDGYLYGRGAADMKGSLAAMIVATERF
VAKHPNHPGSIAFLITSDEEGPFINGTTRVIDTLEARNEKITWTLVGEPSSTLKLGDVVK
NGRRGSLTANLTVKGIQGHVAYPHLADNPIHKAAPFLAELSQTHWDNGNEFFPPTSMQIA
NINGGTGASNVIPGTLEVMFNFRYSTEVTAEILIERVEALLTAHELDYDISWTFNGLPFL
TGEGPLLDATRHAIRQITGYDTDPQTTGGTSDGRFIAPTGAKVLELGPVNATIHKVNECV
KIDDLEQLALCYEVILEQLLC