Protein Info for Shewana3_1677 in Shewanella sp. ANA-3

Annotation: 6-phosphogluconate dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)
  • amino acids 9 to 499 (491 residues), 581.1 bits, E=8.8e-179
• PF03446: NAD_binding_2
  • amino acids 9 to 174 (166 residues), 113.8 bits, E=8.6e-37
• PF00393: 6PGD
  • amino acids 206 to 498 (293 residues), 418 bits, E=2.1e-129

Best Hits

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 100% identity to shn:Shewana3_1677)

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

• pentose phosphate pathway (8/8 steps found)
• superpathway of glucose and xylose degradation (14/17 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Glutathione metabolism
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

See A0KVU1 at UniProt or InterPro

Protein Sequence (508 amino acids)

>Shewana3_1677 6-phosphogluconate dehydrogenase (RefSeq) (Shewanella sp. ANA-3)
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQELR
ITGCANLSEMLASLAHPRILVLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTV
EREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQNVAPIWKAIAAKVDPQTGLP
IERFEPGNPVTDGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMLDGLGMSAA
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGQPLVEMILDKAGQKGTGLWTAVSSLQ
IGCPAPTIAEAVYARAVSTQKSLRVELSKKLAGPASVAMDDAQKASLIDALESALYCAKV
CCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATFLQSITQAYQADADLSCLLMA
DIFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HTFERLDKPAGEKYHLDWSAPNRVLIKL