Protein Info for Shewana3_1497 in Shewanella sp. ANA-3

Annotation: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 748 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 10 to 35 (26 residues), 16.7 bits, see alignment (E = 3.6e-07) PF20256: MoCoBD_2" amino acids 22 to 191 (170 residues), 53.7 bits, see alignment E=2.3e-18 amino acids 615 to 697 (83 residues), 53.9 bits, see alignment E=2e-18 PF02738: MoCoBD_1" amino acids 316 to 542 (227 residues), 88.3 bits, see alignment E=4.6e-29

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 100% identity to shn:Shewana3_1497)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KVB2 at UniProt or InterPro

Protein Sequence (748 amino acids)

>Shewana3_1497 aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead (RefSeq) (Shewanella sp. ANA-3)
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLSWSPMALAQDQQARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQILAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MREMGAMARTMLEQAAAARWKVPVSEVQAKDHQVLHAKSGRAARFGELALDAAGLPLPTA
DSLRLKAVKDFKQIGASRQIVDMQAMLTGKAVYGYDIQVDNMLYASIMRPPVLGSDVASL
DDSAARKVAGVVDVYRLPTSKGAPAFQALGGVAVVATNTWSALQGRKALQVSWTQSANSS
HDSKTYLQELVDKVQAPGKVVRQVGDEVKAWPKDDTLKAIYTVPYLIHSSIEPPVATANV
TEKGCEIWASTQTPQSTQQNVAVALGIAEDAVKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPVKVSWSREDEIQNGYYHAISAQCYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALANLRYEAVKASAHSRIGWMRSVCNIQHGFGVGSFVDEMAHKA
KLSCPDMWRSLLGQARRETFENQGFKYGNYGEDLTRHPVDVGRYLKVIEAVEQAQAKAPK
AGKNQGWGFAVHRSFVSVVAVAMRVEVGEDKQLKVLNAIAAIDAGTVVNPDRVKAQTEGA
IVFGLSLALMGEISYQQGKVMQSNFHDYPLLRLPQVPEMEVIIIDSDAPPAGVGEPGVPP
VAPSLTNAIFAATGLRIRDLPVNKQLKV