Protein Info for Shewana3_1160 in Shewanella sp. ANA-3

Annotation: ATP-dependent protease, putative (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 805 PF20437: LonC_helical" amino acids 96 to 129 (34 residues), 54.6 bits, see alignment (E = 1.7e-18) PF13654: AAA_32" amino acids 325 to 456 (132 residues), 170.6 bits, see alignment E=3.5e-54 PF20436: LonB_AAA-LID" amino acids 484 to 548 (65 residues), 81.8 bits, see alignment E=5.9e-27 PF05362: Lon_C" amino acids 658 to 764 (107 residues), 37.2 bits, see alignment E=4.9e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to she:Shewmr4_1159)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KUC6 at UniProt or InterPro

Protein Sequence (805 amino acids)

>Shewana3_1160 ATP-dependent protease, putative (RefSeq) (Shewanella sp. ANA-3)
MPTVPTATPAIPLTSQQLYRKSELKQLNPECQSTAQLTPLDDIVGQERAQQAVEFAMGIK
EKGYNIYAIGQNGLGKRTMMLRYLNRHDPIEPSLFDWCYVVNFDDTRSPKVLKLTAGTGQ
EFKKSIEKLMLKLVKALPLAFDNEMYYARAEKLKSQLAQKQEAALTELSEEAKQKNISLS
LTLQGDYQMVALNGEEPHDEVSFGALTEAERAQFESNINGLEVKLRGIIRQNTEWEEEFS
DTQQEHDEQVAKDVLVHFFKPLKDKYKHQPEVRAFLTGMQSDILSNLDIFLEESEEQLAL
AYASLEKKMPRRYQVNVIVCQGEQKFPIVVEESPSYHSLFGYVENATFRGTVFTDFSLIR
PGSLHKANGGVLLMDAIKVLERPYVWDGLKRALRSRKLDLSSLEREVSLSGTISLAPEPI
PLDVKIILFGDHETYQLLQHYDPDFSELFRITADFEDVMDRTDISEAQYARFISSIVHDN
NMLHCDRSAIARIIEYSSREAQDQQKLSLHSANIANLLRESNFCAKAAASQCIEKQHVEQ
ALKNQEQRVSRLHDNIMESFINGTTLINTHDKVVGQINALSVISTSDHQFGLPNRITATT
AFGKGEVLDIEHRVKLGGRIHSKGVLILTAYLASVLGKTAQIPLTTYLTFEQSYSGVDGD
SASMAECCAIISAISELPLRQDIAITGSMNQFGEAQPIGGVNEKIEGFFDVCKIKGRSSS
QGVIIPESNIANLMLRQDIVEAVERGEFHIWAISHVTQAMALLLGKTAATLGGDDGKHAG
HYAPECVFGIAQQKLNALRALPKAN