Protein Info for Shewana3_1136 in Shewanella sp. ANA-3

Annotation: Trp operon repressor (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 91 PF01371: Trp_repressor" amino acids 4 to 89 (86 residues), 109.3 bits, see alignment E=4e-36 TIGR01321: trp operon repressor" amino acids 5 to 88 (84 residues), 72.3 bits, see alignment E=1.7e-24

Best Hits

Swiss-Prot: 38% identical to TRPR_VIBCH: Trp operon repressor homolog (trpR) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03720, TrpR family transcriptional regulator, trp operon repressor (inferred from 100% identity to shn:Shewana3_1136)

Predicted SEED Role

"Transcriptional repressor protein TrpR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KUA2 at UniProt or InterPro

Protein Sequence (91 amino acids)

>Shewana3_1136 Trp operon repressor (RefSeq) (Shewanella sp. ANA-3)
MRANWDLVLEKILSHGNYEELSVLFHLLLTEEERSAIAGRLKVFQLLLDGEMSQRQIAAE
YEVSIATITRCSNYLKNMAPSHREKIQQLIK