Protein Info for Shewana3_1042 in Shewanella sp. ANA-3

Name: deoA
Annotation: thymidine phosphorylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02643: thymidine phosphorylase
  • amino acids 2 to 438 (437 residues), 724.2 bits, E=5.8e-222
• TIGR02644: pyrimidine-nucleoside phosphorylase
  • amino acids 5 to 423 (419 residues), 528.4 bits, E=1.2e-162
• PF02885: Glycos_trans_3N
  • amino acids 5 to 67 (63 residues), 69.3 bits, E=3e-23
• PF00591: Glycos_transf_3
  • amino acids 79 to 309 (231 residues), 154.3 bits, E=7e-49
• PF07831: PYNP_C
  • amino acids 350 to 423 (74 residues), 77.9 bits, E=5.5e-26

Best Hits

Swiss-Prot: 100% identical to TYPH_SHESA: Thymidine phosphorylase (deoA) from Shewanella sp. (strain ANA-3)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 100% identity to shn:Shewana3_1042)

MetaCyc: 68% identical to thymidine phosphorylase (Escherichia coli K-12 substr. MG1655)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.3]; Thymidine phosphorylase. [EC: 2.4.2.2, 2.4.2.3, 2.4.2.4]

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
• pyrimidine deoxyribonucleosides degradation (3/3 steps found)
• pyrimidine ribonucleosides degradation (2/2 steps found)
• superpathway of pyrimidine ribonucleosides degradation (2/5 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.3

Use Curated BLAST to search for 2.4.2.2 or 2.4.2.3 or 2.4.2.4

Sequence Analysis Tools

See A0KU08 at UniProt or InterPro

Protein Sequence (443 amino acids)

>Shewana3_1042 thymidine phosphorylase (RefSeq) (Shewanella sp. ANA-3)
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALT
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
GGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
SLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKL
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELG
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEEAFAQAEEAVKKA
IHIDEVAPEKTPEIYAYIRASDL