Protein Info for Shewana3_0586 in Shewanella sp. ANA-3

Annotation: MscS mechanosensitive ion channel (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1067 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 446 to 464 (19 residues), see Phobius details amino acids 494 to 516 (23 residues), see Phobius details amino acids 522 to 548 (27 residues), see Phobius details amino acids 569 to 588 (20 residues), see Phobius details amino acids 600 to 622 (23 residues), see Phobius details amino acids 643 to 663 (21 residues), see Phobius details amino acids 669 to 690 (22 residues), see Phobius details amino acids 750 to 769 (20 residues), see Phobius details amino acids 804 to 827 (24 residues), see Phobius details amino acids 840 to 860 (21 residues), see Phobius details amino acids 872 to 899 (28 residues), see Phobius details PF12794: MscS_TM" amino acids 446 to 784 (339 residues), 324.2 bits, see alignment E=1.7e-100 PF21088: MS_channel_1st" amino acids 845 to 886 (42 residues), 38 bits, see alignment (E = 2.6e-13) PF00924: MS_channel_2nd" amino acids 888 to 953 (66 residues), 87.1 bits, see alignment 1.4e-28 PF21082: MS_channel_3rd" amino acids 963 to 1043 (81 residues), 56 bits, see alignment 9.1e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to shn:Shewana3_0586)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KSQ6 at UniProt or InterPro

Protein Sequence (1067 amino acids)

>Shewana3_0586 MscS mechanosensitive ion channel (RefSeq) (Shewanella sp. ANA-3)
MPRILLFVIAFLSFSLHANSPLQLDKRLGLNNQNQQQNISIDDQIVELKNNIDRLAANAN
SFQQAQLDFEENKKVIDHGLKEAAKPLKLDKATDLNQQASMAYLRLSELKESETALGNQV
SELLQRHNLLPSVIANARQNVLQNKKTELAPLDTPAGELQQTQRVFFEQSLATNEAELAS
SQKRIELTQLQLQLVRQQLSQQEAFIETINKAMNKQRQQQTDATLAKNLVDTAKVVDPVT
RNIADTNQIYGQKLQTLTLQINNVVEQQEQAELQYQSQAKQLANIQEQITWVKMNSAFGE
RFLQMLQSLPKPPNHEKLQTLIADARLDRYHLEQQQALNEQELEQTNLYNEGQIKLLRSQ
QALLTQLMQSYDQYLSELGKLKVNYQQLSQQHLTLKNTLNEHLFWVPNAASINKLWLTDL
QRSALWLVQEAQWGQLGKAWQEQNDYWSWWIILLVLCLVIQDLIRPKFKRLLTHYVTYVG
NVTQDKFIYTFKSLVLSLGYALIKPLPIVAAGWIFYQSERNFVQAVGMGILAIGLVYLLY
RLIFILALDKGVLVGHFKRPSKLIQAGQLRLKHFVFVASPLLGIMGFTEVLDASLIRNSI
GRGAFICFCVVLFLLYKDILVLSRQNSDTQKDGKNKRLIQKMLWALLISVPLLSAVLAFR
GYYFTAFQMLLQLQLSIVLGLSFLLLYQLIKRWMLIERRRIAFDRAKAKRAERLAQREKG
ETHHVSSDGLDTYEEPVVDLETISSQSLGLVRSLLLLAFLASLIGLWTQTHTALFSFLDG
ITLWTTNTSVNGVEQQLPITMKSLLLGLVIVGFSLMIATNLPGLLELMILQRLDLTPGTG
FAITTVSRYLVVFLGLLIGFSNLGMEWSKLQWLIAALSLGLGFGLQEIFANFISGLIILF
EKPVRIGDTVTIRDLTGTVSKIQIRATTIIDWDRKEIIIPNKAFITEQLINWSLSDPITR
VIVHVSVARDSDPAKVEATLYQAVQECEDALPNPEPEVWFAGFGKHTQDYEVRAYAKEMS
ARWPLRHDLHKRITRKLKENNLELAYPQMEIHLKNGQTRDQVGIIRS