Protein Info for Shewana3_0578 in Shewanella sp. ANA-3

Annotation: serine/threonine protein kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 PF00069: Pkinase" amino acids 44 to 255 (212 residues), 75.8 bits, see alignment E=5.5e-25 PF07714: PK_Tyr_Ser-Thr" amino acids 48 to 197 (150 residues), 36.6 bits, see alignment E=4.7e-13

Best Hits

KEGG orthology group: K08282, non-specific serine/threonine protein kinase [EC: 2.7.11.1] (inferred from 100% identity to she:Shewmr4_0579)

Predicted SEED Role

"Protein kinase"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KSP8 at UniProt or InterPro

Protein Sequence (602 amino acids)

>Shewana3_0578 serine/threonine protein kinase (RefSeq) (Shewanella sp. ANA-3)
MQTPQLQHFYISEEQSIYLLKANDARKHKAWIRLCKQQLSKLGYRDIEFIGKGAYGFVFA
GINQADEAHVFKFSRINLPQHIQDRLEEEAFMLSLLKHPNIPGAIKFERVGKQGILVMER
AKGEDLEQLCRRLGALPPAMVMSIARQLADILYYLRTGKPLVHGDIKPSNLVYDIESQHL
SLIDWGSAVFAQRDEHNKAVEDNVMTLMSSDQQHTNARMGDVYFIGEEQLNGALSSPRFD
EQGVAATLYALASGQASRFGAQVIPPTSIGLPMELARTLEGMLSSDAVQRNLAGDYFLKS
MRHSHRIHLPELPKTELLGEIPVWVQSREKDVETVSYSSRKSFLKEHNAQDPIAKMDDIQ
LEKYYRNFLAGMGDTEKGFIAAVGRLGQYPIVGGLAIHWQETGVFIDSNLAIYDAKQKSA
LIIAVNNMVTLARGIKRIGVFKACFFNARDTLHIERENTSEPFVASADLQLPFEVGDVPT
LEDKSRLHSYFEDGKDPDENLELPSEIMEELARINQIHHTGCIIFEALPNHLKIHSYLKL
LNPRKQAAFRASLDRILHYVGKIQGHGVSGFMKLPYKNTRRFTHIERKAEHFYPRNPKEI
GA