Protein Info for Shewana3_0522 in Shewanella sp. ANA-3

Annotation: secretion protein HlyD family protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 351 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF16576: HlyD_D23" amino acids 38 to 286 (249 residues), 73.8 bits, see alignment E=2.5e-24 PF13533: Biotin_lipoyl_2" amino acids 46 to 90 (45 residues), 33.4 bits, see alignment 6e-12 PF00529: CusB_dom_1" amino acids 91 to 337 (247 residues), 46 bits, see alignment E=8e-16 PF13437: HlyD_3" amino acids 210 to 292 (83 residues), 61.3 bits, see alignment E=2.7e-20

Best Hits

KEGG orthology group: K03543, multidrug resistance protein A (inferred from 100% identity to shn:Shewana3_0522)

Predicted SEED Role

"Multidrug resistance protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KSJ3 at UniProt or InterPro

Protein Sequence (351 amino acids)

>Shewana3_0522 secretion protein HlyD family protein (RefSeq) (Shewanella sp. ANA-3)
MSKSKLIIAVPLLLAAVAGGGYYWWTQVRFIETTDNAYVEADISHVSVKVPGYVVLSDVT
DNQHVRKGELLAQLEDNQFSAKVSQAEALLASAKADMQTLAAKVELQHALISQASAGVVA
AQADKLRAEQQLSRAKKLKVSNYSSQDDVDQLQAGFDSAAAGLDEAKALLVAKERELAVF
NAQLNQAGSVVEQSNAALELAKIQLNDTRVTAPFSGVIGKRGAMVGQYVQPGQALYSLVP
DGAVWITANFKETQIQHMQPGQSVQVSLDAFPDKTFTGVIDSLSPASGAKFSLLPAENAT
GNFTKIVQRIPVRIRLDLSAEEARVVPGLSAVVKVDTASHPTTAIAANVGR