Protein Info for Sama_2719 in Shewanella amazonensis SB2B

Annotation: glycine dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 962 transmembrane" amino acids 753 to 771 (19 residues), see Phobius details TIGR00461: glycine dehydrogenase" amino acids 18 to 955 (938 residues), 1530.3 bits, see alignment E=0 PF02347: GDC-P" amino acids 18 to 439 (422 residues), 587.8 bits, see alignment E=1.3e-180 amino acids 463 to 751 (289 residues), 48.8 bits, see alignment E=5.1e-17 PF21478: GcvP2_C" amino acids 782 to 903 (122 residues), 197.9 bits, see alignment E=4.4e-63

Best Hits

Swiss-Prot: 71% identical to GCSP1_COLP3: Glycine dehydrogenase (decarboxylating) 1 (gcvP1) from Colwellia psychrerythraea (strain 34H / ATCC BAA-681)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 72% identity to asa:ASA_2631)

MetaCyc: 68% identical to glycine decarboxylase (Escherichia coli K-12 substr. MG1655)
Glycine dehydrogenase (decarboxylating). [EC: 1.4.1.27, 1.4.4.2]

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.27 or 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S965 at UniProt or InterPro

Protein Sequence (962 amino acids)

>Sama_2719 glycine dehydrogenase (RefSeq) (Shewanella amazonensis SB2B)
MTKQTLTELEQHELFLTRHIGPDADEQQAMLNYVGAESLEDLTAQIVPESIRLGRELNVG
ASNGEAAGLAYIRQLADKNQVFKSYIGMGYHGTEVPNVILRNVLENPGWYTAYTPYQPEI
AQGRLEAILNFQQLSIDLTGLDLASASLLDEATAAAEAMALAKRVSKAKKANTFFVADDV
FPQTLDVVKTRAECFGFDIVTGPAAEAANHDDLFGALFQYTNRQGQLTDFTELFAQLRAK
NVIVTVGADIMSLVLLKSPGAMGADVVFGSAQRFGVPMGFGGPHAAFFVSKDEHKRSMPG
RIIGVSKDTRGKTALRMAMQTREQHIRREKANSNICTAQVLLANMASFYAVFHGPQGLKV
IANRIHRLTDILAAGLAAKGVTVLNTQWFDTLSFKVDVDAVRARALAAGVNLRYDADGVV
GVSLAETTTRADVAELFDIILGAGHGLDVAAIDADILAKGSSSIPAALVREEAFLTHPTF
NSYHSETEMMRYIKRLENKDLALNHSMISLGSCTMKLNAAVEMIPVSWPEFANMHPFCPS
EQAQGYTQLIGELSDWLVDITGYDAVCMQPNSGAQGEYAGLLAIRKYHESRGEGHRDVCL
IPQSAHGTNPASAQLAGMKVVVTACDKQGNVDLDDLRAKAAEVAENLSCIMITYPSTHGV
YEETVREICDIIHQHGGQVYLDGANMNAQVGLTAPGFIGADVSHLNLHKTFAIPHGGGGP
GMGPIGVKKHLAPFVAGHAVVKQGIESDNNGAVSAAPFGSAGILPISWMYIKLLGSKGLK
QSTQTAMLNANYLTKKLSEHYPVLYRGRNDRIAHECIIDMRPLKEASGVTEMDVAKRLND
YGFHAPTMSFPVAGTLMIEPTESESKAELDRFIEAMVAIRGEIARVESGEWPVDNNPLAN
APHTMDDIMDPAFDSRPYSRELAVFPTESVRANKFWPTVNRIDDVYGDRNLFCACVPMSD
YE