Protein Info for Sama_1942 in Shewanella amazonensis SB2B

Name: hisD
Annotation: histidinol dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 transmembrane" amino acids 127 to 147 (21 residues), see Phobius details PF00815: Histidinol_dh" amino acids 27 to 425 (399 residues), 537 bits, see alignment E=1.7e-165 TIGR00069: histidinol dehydrogenase" amino acids 33 to 424 (392 residues), 519.2 bits, see alignment E=4.1e-160

Best Hits

Swiss-Prot: 68% identical to HISX_SHEON: Histidinol dehydrogenase (hisD) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 100% identity to saz:Sama_1942)

MetaCyc: 61% identical to histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655)
Histidinol dehydrogenase. [EC: 1.1.1.23]

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S6Z1 at UniProt or InterPro

Protein Sequence (435 amino acids)

>Sama_1942 histidinol dehydrogenase (RefSeq) (Shewanella amazonensis SB2B)
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEI
DTLALSADEIAAACERVSPELKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEA
IEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPPPIDDAILYAASVCGITDVFQ
IGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGAL
SCSRIIITATLDEAAIVSNLYAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYA
SGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKGLGQTVMTLAAAESLDAHKNA
VKVRLDAIAREENRQ