Protein Info for Sama_1313 in Shewanella amazonensis SB2B

Annotation: heat shock protein 90 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 637 PF02518: HATPase_c" amino acids 29 to 182 (154 residues), 35.9 bits, see alignment E=1.3e-12 PF13589: HATPase_c_3" amino acids 30 to 169 (140 residues), 42.2 bits, see alignment E=1.2e-14 PF00183: HSP90" amino acids 222 to 636 (415 residues), 441.4 bits, see alignment E=8.9e-136

Best Hits

Swiss-Prot: 100% identical to HTPG_SHEAM: Chaperone protein HtpG (htpG) from Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 100% identity to saz:Sama_1313)

MetaCyc: 68% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S564 at UniProt or InterPro

Protein Sequence (637 amino acids)

>Sama_1313 heat shock protein 90 (RefSeq) (Shewanella amazonensis SB2B)
MSHQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDSLYEGD
GELRVRVSADKDKGTVTIEDNGIGMTRDGVIEHLGTIAKSGTAEFFKNLSGDSAKDSQLI
GQFGVGFYSAFIVAKRVEVFTRAAGHSADEGVKWESEGEGNFSVETITKAERGTKIVLHL
RDEEKEFADDWRLRSIITKYSDHISIPVEMYQEGTPERDGPDGEKIPATEGQWKAMNKAT
ALWTRSKSDVSDEEYKEFYKHISHDFADPLDWSHNKVEGNQEYTSLLYIPAKAPWDLWNR
DRKHGLKLFVQRVFIMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNKVTRNLRQA
LTKRVLSMLEKLAKDDADKYQQFWAEFGTVLKEGPAEDFANRERIAGLLRFASTHTGDAT
PSVSLDDYIGRMKEGQEKIYYIVADSHEAAANSPHLELLKKKGIEVLLLSERIDEWLINH
LHDYKEKALHSVTRGDLDLGALEDEAEKAAQEKLAQESEPLVERFKSALGDKVSDVKITT
RLTDTPACVVTGEGEMSSQMIKLMQAAGQPVPESKPTLELNPTHPLVARLDKEQDETAFA
EWAEMLLAQATLSERGSLADPSAFIKLVNQMLLKSVG