Protein Info for Sama_1141 in Shewanella amazonensis SB2B

Name: pyrH
Annotation: uridylate kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02075: UMP kinase
  • amino acids 10 to 240 (231 residues), 336.2 bits, E=5.2e-105
• PF00696: AA_kinase
  • amino acids 11 to 219 (209 residues), 110.9 bits, E=4.3e-36

Best Hits

Swiss-Prot: 100% identical to PYRH_SHEAM: Uridylate kinase (pyrH) from Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)

KEGG orthology group: K09903, uridylate kinase [EC: 2.7.4.22] (inferred from 100% identity to saz:Sama_1141)

MetaCyc: 84% identical to UMP kinase (Escherichia coli K-12 substr. MG1655)
Cytidylate kinase. [EC: 2.7.4.14, 2.7.4.22]

Predicted SEED Role

"Uridine monophosphate kinase (EC 2.7.4.22)" (EC 2.7.4.22)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• CMP phosphorylation (2/2 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.14

Use Curated BLAST to search for 2.7.4.14 or 2.7.4.22

Sequence Analysis Tools

See A1S4P2 at UniProt or InterPro

Protein Sequence (241 amino acids)

>Sama_1141 uridylate kinase (RefSeq) (Shewanella amazonensis SB2B)
MSTNPKPAFRRILLKLSGEALMGSEGFGIDPSVLDRMAQEIKELVELGIQVGVVIGGGNL
FRGEGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLKGVCDDYNWA
EAISLLKSGRVVIFAAGTGNPFCTTDSAACLRGIEIEADVVLKGTKVDGVYSADPMKDPE
AVKYDELSYAEVLDKELKVMDLSAFTMARDHDMPILVFNMNKPGALRRVIMGEGEGTIIK
K