Protein Info for Shew_3734 in Shewanella loihica PV-4

Annotation: DNA protecting protein DprA (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 339 TIGR00732: DNA protecting protein DprA" amino acids 47 to 257 (211 residues), 248.3 bits, see alignment E=2.5e-78 PF02481: DNA_processg_A" amino acids 50 to 258 (209 residues), 260.3 bits, see alignment E=1e-81 PF17782: WHD_DprA" amino acids 285 to 332 (48 residues), 40.2 bits, see alignment 2.9e-14

Best Hits

KEGG orthology group: K04096, DNA processing protein (inferred from 100% identity to slo:Shew_3734)

Predicted SEED Role

"Rossmann fold nucleotide-binding protein Smf possibly involved in DNA uptake" in subsystem Conserved gene cluster associated with Met-tRNA formyltransferase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QJF2 at UniProt or InterPro

Protein Sequence (339 amino acids)

>Shew_3734 DNA protecting protein DprA (RefSeq) (Shewanella loihica PV-4)
MDVAELRQRLEHEPDALPLPERLLTAKLSPDFSLVEQALAWQDAAPHHHILCPQDTLYPS
LLLQLNDPPPILFAKGDPNALVHPCIAMVGSRAASQSGLAASYQLAQELTAAKIAVISGM
AAGIDGAAHQGVLDADGVTLAVLGTGIEVIYPKRHKPIYEKIQQRGCVLSEFWPQIKPYA
GNFPKRNRIISGLSLGVLVVEAARKSGSLITARFALEQGREVFAVPGNILAGDHQGCHDL
LRDGAKLVECAADIIEEVAALSKFHLEELHRRHHIGEELASDLPFASLLASVGYEATPLD
VVVEHSGKTIELVLEQLLELELQGWVSAVPGGYIRLKRS