Protein Info for Shew_3630 in Shewanella loihica PV-4

Annotation: bioH protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 259 TIGR01738: pimelyl-[acyl-carrier protein] methyl ester esterase" amino acids 12 to 250 (239 residues), 264.6 bits, see alignment E=4.7e-83 PF00561: Abhydrolase_1" amino acids 16 to 220 (205 residues), 73.7 bits, see alignment E=2.9e-24 PF12146: Hydrolase_4" amino acids 17 to 216 (200 residues), 43.6 bits, see alignment E=3.4e-15 PF12697: Abhydrolase_6" amino acids 17 to 248 (232 residues), 75.9 bits, see alignment E=1.2e-24

Best Hits

Swiss-Prot: 66% identical to BIOH_SHEWM: Pimeloyl-[acyl-carrier protein] methyl ester esterase (bioH) from Shewanella woodyi (strain ATCC 51908 / MS32)

KEGG orthology group: K02170, biotin biosynthesis protein BioH (inferred from 100% identity to slo:Shew_3630)

Predicted SEED Role

"Biotin synthesis protein BioH"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QJ48 at UniProt or InterPro

Protein Sequence (259 amino acids)

>Shew_3630 bioH protein (RefSeq) (Shewanella loihica PV-4)
MSQQSLHIETIGQGRPIVLLHGWGVNSAVFTPLHHTLKDHQLLLVDLPGFGDSPAIEGDL
DAWVDHLMEQLPERAIWAGWSLGGLVATRAALRYPERINALLTIASSPCFMARDNEGWPG
IPPQILGQFGDQLEKDLGKMIERFLAIQAMGSETAKQDIKQLRDLVMAKPLPDADALRAG
LQMLKEVDLRDQLNEIRVPWLRVWGRLDGLVSRRVQPLMPVCESRFVDFVLPKASHAPFF
SHRDAFVQGVEAWLQTLKE