Protein Info for Shew_3521 in Shewanella loihica PV-4

Annotation: tryptophan halogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 PF03486: HI0933_like" amino acids 14 to 45 (32 residues), 24.5 bits, see alignment (E = 4.9e-09) PF01494: FAD_binding_3" amino acids 14 to 348 (335 residues), 62.7 bits, see alignment E=1.6e-20 PF12831: FAD_oxidored" amino acids 15 to 176 (162 residues), 39.4 bits, see alignment E=2.2e-13 PF04820: Trp_halogenase" amino acids 15 to 98 (84 residues), 37.5 bits, see alignment E=6.4e-13 PF00890: FAD_binding_2" amino acids 15 to 47 (33 residues), 23.1 bits, see alignment (E = 1.8e-08) PF13450: NAD_binding_8" amino acids 18 to 47 (30 residues), 32.4 bits, see alignment (E = 4e-11)

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_3521)

Predicted SEED Role

"FIG022199: FAD-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QIT9 at UniProt or InterPro

Protein Sequence (424 amino acids)

>Shew_3521 tryptophan halogenase (RefSeq) (Shewanella loihica PV-4)
MTPFAQTAAQTDHYDVIVIGAGPSGSVAASLLHQQGKRVLVLEKQHFPRFSIGESLLPCC
MQVIAEANMLDAVNQAGYQFKNGAAFNANGRSTYFDFTDKFTPGPGTTFQVERGDFDKLL
ADTAASQGVEIRYGQRVDAVDLSHNPRLTISDEQGASYELSADYLLDASGFGRVLPRLLD
LERPSNLPSRTAIFTHIQDNIDSVDMGDYHFDRNKILISVHPDNRDIWYWLIPFSNGRCS
LGVVGEPHLLGQDADLEATNLEATLIRLVREEPRLKQLLSRAEIIRKPAKLAGYSANVST
LASDKFALLGNAGEFLDPVFSSGVTIAMQSASIAAKCVVKQLNGESVDWQTEYAQPLMRG
VDTFRTYVQAWYDGRFQDVIFYQDPNPKIKQMICSILAGYAWDESNPFVAESERRLNMVV
ELCR