Protein Info for Shew_3200 in Shewanella loihica PV-4

Annotation: multi-sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1768 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 302 to 326 (25 residues), see Phobius details PF22673: MCP-like_PDC_1" amino acids 93 to 207 (115 residues), 124.7 bits, see alignment 1.2e-39 TIGR00229: PAS domain S-box protein" amino acids 405 to 506 (102 residues), 24.4 bits, see alignment 1.3e-09 amino acids 514 to 635 (122 residues), 55 bits, see alignment 4.4e-19 amino acids 639 to 767 (129 residues), 43.7 bits, see alignment 1.4e-15 amino acids 901 to 1026 (126 residues), 44 bits, see alignment 1.1e-15 PF13426: PAS_9" amino acids 408 to 505 (98 residues), 26.2 bits, see alignment 4e-09 amino acids 521 to 629 (109 residues), 43.7 bits, see alignment 1.4e-14 amino acids 665 to 760 (96 residues), 21.5 bits, see alignment 1.1e-07 amino acids 792 to 891 (100 residues), 13.6 bits, see alignment 3.3e-05 amino acids 916 to 1017 (102 residues), 27.6 bits, see alignment 1.5e-09 PF00989: PAS" amino acids 515 to 606 (92 residues), 31.4 bits, see alignment 8.3e-11 amino acids 904 to 1016 (113 residues), 39.6 bits, see alignment 2.4e-13 PF13188: PAS_8" amino acids 515 to 561 (47 residues), 24.4 bits, see alignment (E = 1e-08) amino acids 905 to 960 (56 residues), 26.9 bits, see alignment (E = 1.7e-09) PF08447: PAS_3" amino acids 668 to 753 (86 residues), 62.1 bits, see alignment 2.5e-20 amino acids 800 to 882 (83 residues), 33.6 bits, see alignment 2e-11 PF08448: PAS_4" amino acids 910 to 1019 (110 residues), 29.3 bits, see alignment 4.3e-10 PF00512: HisKA" amino acids 1039 to 1104 (66 residues), 80.2 bits, see alignment (E = 4.7e-26) PF02518: HATPase_c" amino acids 1151 to 1265 (115 residues), 99.5 bits, see alignment 7.7e-32 PF00072: Response_reg" amino acids 1284 to 1392 (109 residues), 85.9 bits, see alignment 1.1e-27 amino acids 1426 to 1536 (111 residues), 89.8 bits, see alignment 6.8e-29 PF01627: Hpt" amino acids 1594 to 1668 (75 residues), 33.1 bits, see alignment (E = 2.7e-11)

Best Hits

KEGG orthology group: None (inferred from 70% identity to shl:Shal_0720)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QHW8 at UniProt or InterPro

Protein Sequence (1768 amino acids)

>Shew_3200 multi-sensor hybrid histidine kinase (RefSeq) (Shewanella loihica PV-4)
MDMSRLRTFRSRIIVQIALPLIAIMAMVLSLIAWFNYRAEESYLYGDLEKQAEMVASRVH
HFLSFAEEDTRTFADLLGQMSRDQLVHQDGELKALLTRRLERQSDFYASAIAFRPSLTPN
QQPYAPYVYRDQDGVKFLDIGADSYDYTDGQWAWWSEAIDKPQGYWSLPYFDEGAGNILM
ITFSHPFGPSSPYWGVVTVDLALDALPAMAGIDADRMLVLDDKGRLIYHKDAQLLMSQGT
DKWLAPSNDNGDFITLLQSAKSGNSRMLAADGQAYLASVGVVPKLNWRVVIMTQEDKLSH
QLYMGLSSLVLTLLLISAVLYLTGYLTARRLSLPIERLAAGIVAFGAGKTKHIEGTRGAV
TEVETLTDKFNELAEVLAQREQALLDSRGNRFAKLIDGMSDKSFYCSLEPDGQIAQVSAG
VEKVLGVSPDLLKRKYQRMFSDNPINEANWEYMDSALQGNSVPPHQVEMIAANGSVRRLD
LFMQPLLSDNGELLSIEMLFNDVTEQFSAAAWSNAVLESAPEAMLIVDEQGQVVFSNSRC
QQLFGYDAQQMLALNVDQLVPDSVKHHEALRAKFIGEGVDRRMGLGLGKTLKAKKADGSL
FPVEISLGLLPADSDGLRQVAASIRDMTEELATAKRIKDSESRFRGLVGNIPGAVYRTRL
GEQWVMEYVSDNIAEITGYPAADFIENKKRVFASLILEADREATDTAINKGIAEQQSFEV
QYRIQHRDGSLRWVHEKGKASYDDEGNALWFDGSIQDVTQSKLAQEKIAQSQQQLETITE
SIPNTVYQLRWIANDQRYFTFLSRACITTLGFHRDQLLANFDLVADCIIESERARIIRAL
SGESASGLKWIEEFRYQHPTGEQRWLQAGARGDRQDDGSIVWNGYLMDISERKQMDRELA
KREAHFRALFDNAGIGIVNVDDRGVILDCNEQFSQYLQLPIERLKGSLFFDYQDPEQGLE
AKNSFKHLMGDGADSVKLEIRLLNQAGEARWMDVNMTGLSDKQGEYRSAVLSMADISSLK
LLSEELTQAKDVADAASKAKSDFLANMSHEIRTPMNAIIGMSQLCLQTSLDKKQQNYVEK
IDRASKSLLGIINDILDFSKIEAGKLDIEAVPFQLDTMLEDLSDMFSVKAADKQLELLFA
VAPNIPRHLVGDPLRLSQVLINLMNNAIKFTEQGEVMLSISQLVREDEEILLKFSVRDNG
IGLTEEQRGKLFQSFSQADSSTTRKYGGTGLGLAICKQLVELMGGEIGVESQFGNGSTFF
FSVRFKVADNQLIKVAQELEGMRILVADDNATARDILRSTLESMGFTVDTVRSGAEALSR
CQETDYGVALIDWRMPEMDGLETARRLLSERTNPPKTLIVSAHADGDFIDKAEQAEISGY
ITKPISASRLLDGIMSALGKQGAMPVRRKGSEVSPALLAQLKGKRILLVEDNEMNQEVAS
EFLEQVGVILSIAENGQVALEKLAMQSFDLVLMDCQMPVMDGYQATAELRKRPELADLPV
IAMTANAMAGDKEMCLRAGMNDHIAKPIEVSLLYKTLLEYLGDDSQVIEETSTEQTDQHS
QDAYWPQHPALDIDKGLQLVQNSARLYRRIFERFYTGQSRCAELIATAQREGKQEEAVRY
AHTLKGVAGNLCCPELVALAKQVEQTLSDSIEADVTEALTQMGELLDSLCTTIGDWLSQT
GAETLPQEDGAEAGATADAPPMSAQELDAAIKELLKMLEEADAEAVEKLQAIRDRLPTSL
ANKIAPVLNMVNAYQFDEAIELVEEIFS