Protein Info for Shew_3125 in Shewanella loihica PV-4

Annotation: diguanylate cyclase/phosphodiesterase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 731 PF00990: GGDEF" amino acids 299 to 452 (154 residues), 124.2 bits, see alignment E=4.5e-40 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 300 to 454 (155 residues), 103.5 bits, see alignment E=5e-34 PF00563: EAL" amino acids 477 to 711 (235 residues), 209.2 bits, see alignment E=6.3e-66

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_3125)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QHP3 at UniProt or InterPro

Protein Sequence (731 amino acids)

>Shew_3125 diguanylate cyclase/phosphodiesterase (RefSeq) (Shewanella loihica PV-4)
MSSDTQQGSQSLEQTLAFLCEHDLEEELQLILQQLAASNQCDGLFLLRIGKGRLPVQIEA
MYQSDASIFSKRDAEMLLSRVANNRHLHSYTSLREPAIVEDVASVIDDEDSRLRLNQAKI
RSVLLLPVGGERHYIFGAYRYDCDGVWLEAIRLNLLLAGSLLGLAQEAARQRLNAKSNEL
VCIEHLYRLPIPCVHIGVDDRVIRYNQSAAESLHVETLQKVETLVPKREQKHLLDTMALV
RDQVLEQSSCEVPLKYAPDDAQAKVTFLCLSGEDGPILMLVEPVGEPVQESEAHSVSLNF
DPLTGLPNRAYFEALYDLANPCQCERSTFVGFINLDRFQVVNNVSGHRAGDQLLCQLAAR
LSQLVRKEDVIARLSGDEFGILMPNIDVQIAEQVAERICQAMANHEFSWEGRSHSVSVSM
GLARCESEVDSVSDLLRRASAACRLAKEKGGNAWYFYSTQDPVVEKLNTEMSASVDIVGA
LANDRFELFYQPIEPLYASDDGLHLEILLRMRSTEGELIPPGIFLPAAERFNLAAKLDRW
VIDKLLRWGSENLALWQSLSMVSVNLSALSISDSEFINWLEMRLLGEPELVSKLCFEITE
TAAVSQLDHATGLINTVKPLGCKLALDDFGSGFSSFAYLKLLDVDYVKIDGQFIQHLCED
RADQAIVAAICQLGRDMAFEIVAEFVESVEVAKHLQKLGVEFGQGYGIARPESLTSLTSG
EGLHWYRVLEG