Protein Info for Shew_2849 in Shewanella loihica PV-4

Annotation: xanthine/uracil/vitamin C permease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 49 to 74 (26 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 131 to 155 (25 residues), see Phobius details amino acids 168 to 186 (19 residues), see Phobius details amino acids 193 to 213 (21 residues), see Phobius details amino acids 238 to 262 (25 residues), see Phobius details amino acids 282 to 304 (23 residues), see Phobius details amino acids 316 to 334 (19 residues), see Phobius details amino acids 342 to 362 (21 residues), see Phobius details amino acids 373 to 399 (27 residues), see Phobius details amino acids 411 to 428 (18 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 17 to 391 (375 residues), 182.7 bits, see alignment E=4.7e-58

Best Hits

Swiss-Prot: 51% identical to ADEP_ECOLI: Adenine permease AdeP (adeP) from Escherichia coli (strain K12)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 100% identity to slo:Shew_2849)

MetaCyc: 51% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGW7 at UniProt or InterPro

Protein Sequence (429 amino acids)

>Shew_2849 xanthine/uracil/vitamin C permease (RefSeq) (Shewanella loihica PV-4)
MLEKVFKLTEHQTTLKQEVVAGLTTFLTMAYIIFVNPMMLADAGMDHGAVFVATCLAAAV
GCLVMGIVANYPIALAPGMGLNAFFTYTVVGEMGYSWETALGAVFLSGICFLILSLVKIR
EWIVNSIPMSLRLGIAAGIGLFLALIGLKSAGIVVASPATLVTMGDVTALPAVMSVLGFF
IIIALVHRGYQSAVIISILGITALGLLLGDVQYSGMISTPPSIAPTFMKMDLSNVLEISM
LSVVFAFLFVDLFDTSGTLVAVAQRGGFLDDRGRLPRLGRALTADSSATIAGAMLGTSTT
TSYIESTAGVSAGGRTGLTAVVVGIMFLLSLFISPLAGMVPAYATAGTLFYVAILMMSGL
VHVDWEDLTEAAPVVVVCILMPLTFSIATGIAMGFVAYAGIKLFSGRYKDLSLGVLVLAA
LFLAKFIYG