Protein Info for Shew_2798 in Shewanella loihica PV-4

Annotation: trimethylamine-N-oxide reductase TorA (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 828 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details TIGR02164: trimethylamine-N-oxide reductase TorA" amino acids 1 to 826 (826 residues), 1577.4 bits, see alignment E=0 PF18364: Molybdopterin_N" amino acids 42 to 82 (41 residues), 46 bits, see alignment 6.1e-16 PF00384: Molybdopterin" amino acids 86 to 558 (473 residues), 225.8 bits, see alignment E=1.3e-70 PF01568: Molydop_binding" amino acids 676 to 803 (128 residues), 77.8 bits, see alignment E=9.8e-26

Best Hits

Swiss-Prot: 85% identical to TORA_SHEMA: Trimethylamine-N-oxide reductase (torA) from Shewanella massilia

KEGG orthology group: K07811, trimethylamine-N-oxide reductase (cytochrome c) 1 [EC: 1.7.2.3] (inferred from 100% identity to slo:Shew_2798)

Predicted SEED Role

"Trimethylamine-N-oxide reductase (EC 1.6.6.9)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 1.6.6.9)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.6.6.9 or 1.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGR6 at UniProt or InterPro

Protein Sequence (828 amino acids)

>Shew_2798 trimethylamine-N-oxide reductase TorA (RefSeq) (Shewanella loihica PV-4)
MNRRDFLKGLAASSYVTLSGSSLLAPLNALASTGTDEVWKTTGSHFGAFKMTRKNGVIDK
VISFDLDKYPTDMINGVKGLVYNPSRVRYPMVRLDFLLKGHKSNTLERGDYRFVRVTWDR
ALSLFKDSLDEIQTKYGPSGLHAGQTGWRATGQLHSSTSHMQRAVGMHGNFVKKVGDYST
GAGQTILPYVLGSTEVYAQGTSWPLILEHSDTIVLWSNDPYKNLQVGWNAETHESYAYLA
QLKEKVAQGKIRVISIDPVVTKTQKYLGCEQLYINPQTDVALMLGIAHEMVSQNLHDKAF
IEGYSLGFDEFLPYLLGEKDGVAKTPEWASQITGVSVEIIKDLAKVMTKGRTQIMMGWCI
QRQQHGEQPYWMAAVLATMIGQIGLPGGGISYGHHYSSIGVPSSGAAAPGAFPRNLDEGQ
KPLFDSSDFKGASSTIPVARWIDAILEPGKTIDANGSKVTYPDIKMMVFSGNNPWNHHQD
RNKMKRAFHKLECVVTIDVNWTATCRFSDIVLPACTTFERNDIDVYGSYANRGVLAMQKM
VEPLYESLSDFEIFTRFAALMGKEKQYTRGLTEMDWLRKLYDECKAANAGKFEMPDFNTF
WQQGYVHFGEGENWTRHSDFRDDPEINPLGTPSGLIEIFSRKIAQFNYDDCPGHPSWMEK
SERSHGGPGSDKYPIWMQSCHPDQRLHSQMCESQEYRETYTVQGREPVYLNPLDAKARGI
KDGDLVRVFNDRGQLLAGARVSNRFPQGVIRIHEGAWYGPVGKDGSKQGGNEIGALCSYG
DPNTLTQDIGSSKLAQACAAYTCLVEFEKFSGKVPEVSAFSGPIEISR