Protein Info for Shew_2774 in Shewanella loihica PV-4

Annotation: TonB family protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 354 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF13374: TPR_10" amino acids 73 to 105 (33 residues), 21.6 bits, see alignment 2.7e-08 PF03544: TonB_C" amino acids 276 to 352 (77 residues), 55.2 bits, see alignment E=1.2e-18 TIGR01352: TonB family C-terminal domain" amino acids 277 to 353 (77 residues), 40.4 bits, see alignment E=1.5e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2774)

Predicted SEED Role

"Ferric siderophore transport system, periplasmic binding protein TonB" in subsystem Campylobacter Iron Metabolism or Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGP2 at UniProt or InterPro

Protein Sequence (354 amino acids)

>Shew_2774 TonB family protein (RefSeq) (Shewanella loihica PV-4)
MKKSLSGLALVLCAHFAAPLSFASPFSESYAAYQQALAGQDKAQVALTAAKAYELGQGYF
ESDSIDLVNLELNLATALQDSGETQAAHEHFNNVIQVYRKHFGRDAIELVDPLIGAAQTM
AASREKVDLFKQAIAIAEDADKPLLLAEVKMLTFHGLASTHFYTREIRDEALEAYEIYRQ
EMPADAMARLKATYYVGMIKAAEKKYDKAVPLLEEVIKQFSVLDFSHPYKLAAHARLVEI
YEAEGESDKSTQHCVAIGSMKPWSDEQEQAPLYREAPKYPISYARDRREGWTQMSFTVDE
QGFVRDPVVLASEGGQQFTRESLKAIKRWRYAPKFVDGKPVPAEVSVQLEYKVN