Protein Info for Shew_2674 in Shewanella loihica PV-4

Annotation: crotonobetainyl-CoA:carnitine CoA-transferase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 PF02515: CoA_transf_3" amino acids 13 to 379 (367 residues), 265.7 bits, see alignment E=3.5e-83

Best Hits

Swiss-Prot: 84% identical to CAIB_SALTI: L-carnitine CoA-transferase (caiB) from Salmonella typhi

KEGG orthology group: K08298, crotonobetainyl-CoA:carnitine CoA-transferase [EC: 2.8.3.-] (inferred from 100% identity to slo:Shew_2674)

MetaCyc: 84% identical to gamma-butyrobetainyl-CoA:carnitine CoA transferase (Escherichia coli K-12 substr. MG1655)
RXN0-3601 [EC: 2.8.3.21]

Predicted SEED Role

"Crotonobetainyl-CoA:carnitine CoA-transferase (EC 2.8.3.-)" (EC 2.8.3.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.8.3.-

Use Curated BLAST to search for 2.8.3.- or 2.8.3.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGE2 at UniProt or InterPro

Protein Sequence (408 amino acids)

>Shew_2674 crotonobetainyl-CoA:carnitine CoA-transferase (RefSeq) (Shewanella loihica PV-4)
MSKKLFTPQFGPLSGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYTDTIRVQPHYP
ELSRRNLHALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLV
VAHLSGFGQYGTEEYTNLAAYNTIAQAFSGYLIQNGDKDQPMPAFPYTADYFSGMTVTTA
ALAALHKVRETGVGESIDVAMYEVMLRMGQYFMMDYFNGGEVCPRMTKGKDPYYAGCGLY
KCADGYIVMELVGAMQIEEMFKDMGISHLWATPEIPEGTQLIHRVECPFGDEVETSLDNY
LNGKTIEAVLARFAELKIACAKVLTIPELEGNPQYQARESITEWTNIDGKAYKGPNVMPK
FKNNPGKIWRGMPKHGMDTEAILSDIGYSAEEIAALSAKGLAKVFEGK