Protein Info for Shew_2669 in Shewanella loihica PV-4

Annotation: penicillin amidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 782 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF01804: Penicil_amidase" amino acids 48 to 764 (717 residues), 438.4 bits, see alignment E=4e-135

Best Hits

KEGG orthology group: K01434, penicillin amidase [EC: 3.5.1.11] (inferred from 100% identity to slo:Shew_2669)

Predicted SEED Role

"Family S45 unassigned peptidase (EC 3.5.1.11)" (EC 3.5.1.11)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGD7 at UniProt or InterPro

Protein Sequence (782 amino acids)

>Shew_2669 penicillin amidase (RefSeq) (Shewanella loihica PV-4)
MLRHLKTLLLILLSLVFMLVVGVYVSLNLSLPKLSGEVQTSQISAKTSIGRDRLGTAVIH
AENRQDAAFTLGFAHGQDRFFQMDLLRRNSAGELAELFGKPAVKLDESRRFHQLRKRAEH
IYRHLPTAQQQLLQRYADGVNRALTAQSLPSFEYLLTRAKREPWRPADSLLVIYSMYLDL
QGNGPKRDLALDHIERSFGPEMRSFITQTSNYQAALDNSLFPSDPPAIPKLSPSPSPSVS
LQQSTASTLAQRLAVTIEEPIEVGSNNWAVTGKMTRTGSAMLSDDMHLSFAVPIIWYRAQ
LNYPDGEGKAVQVTGVSLPGAPAIVVGSNGKLAWGFTNAYIDTADWVALDKDEPLEVVHE
TIKLPKGEQDYAVTLSRFGPVRHLGEQAYALAWVAHQEYAVNMELMALEQIDNVPEAMAK
ASGFGIPVQNLMLADDKGHAAWQLAGAVPARTNGSDIALPSEEIVWDKWQERDKVLPSLQ
DPASDRLWSANARVMSTQEAERYGDGGYALGARSAQIRDRLLEQELFDESDFYRIQLDNQ
ARFYRPWQAFLLESLMREPKRFAKDIVQLRDWQECACAESVGFTLVKAFRSQMLDSAFAP
LEAELNSAQLSLSVLKRYLEPAIWQLLKQQPADWLPQDVASWDELVIASYVTARDELLDK
YSEDGELSALNWGRVNTLAIQHPFSRQFPLLSRWLDMPKVAGFGDTFMPAVQRKSFGASQ
RFIVQPGYEERAIMAVPGGQSGHPLSKYYRAGFSEYARGAATPLLPGEIEAKLTLTPSQM
QD