Protein Info for Shew_2629 in Shewanella loihica PV-4

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 1 to 394 (394 residues), 520.8 bits, E=1.1e-160
• PF02670: DXP_reductoisom
  • amino acids 4 to 131 (128 residues), 146.8 bits, E=8.7e-47
• PF08436: DXP_redisom_C
  • amino acids 145 to 238 (94 residues), 121.4 bits, E=2.2e-39
• PF13288: DXPR_C
  • amino acids 270 to 386 (117 residues), 141.2 bits, E=2.6e-45

Best Hits

Swiss-Prot: 100% identical to DXR_SHELP: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 100% identity to slo:Shew_2629)

MetaCyc: 63% identical to 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli K-12 substr. MG1655)
1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway I (8/9 steps found)
• methylerythritol phosphate pathway II (8/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (10/12 steps found)
• isoprene biosynthesis I (8/10 steps found)
• taxadiene biosynthesis (engineered) (10/13 steps found)
• superpathway of ergosterol biosynthesis II (10/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Sequence Analysis Tools

See A3QG97 at UniProt or InterPro

Protein Sequence (395 amino acids)

>Shew_2629 1-deoxy-D-xylulose 5-phosphate reductoisomerase (RefSeq) (Shewanella loihica PV-4)
MQKMVILGATGSIGASTLSVIEQNPEAYKAFALVAHKSVDKMLDLCIKYNPSIAHMVDPQ
AAAELQRRLPAHMAIAVSSGEDELAAIVALPEVDCVMAAIVGAAGLPATLAAVKAGKRVL
LANKESLVMSGRLFIDAMQGSNAKVLPVDSEHNAIFQCLPEPAQQAIGACDLAGAGISHI
LLTGSGGPFLTSDLDSLSQMTPDQACKHPNWSMGRKISVDSASMMNKGLEYIEARWLFNA
TKEQLKVVVHPQSVIHSMVQYKDGSVLAQMGNPDMRTPIAHCMAYPQRISAGVEPLDFFK
VGQLSFLEPDFNRFPCLKLAIDACEQGQEATTVLNAANEVSVEAFLAGLIRFTDIARVNE
YCLSHVEQRSLDTIEDILALDGLARRAAQERVAKL