Protein Info for Shew_2456 in Shewanella loihica PV-4

Annotation: SMC domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1018 PF13476: AAA_23" amino acids 5 to 225 (221 residues), 63.4 bits, see alignment E=4.9e-21 PF13558: SbcC_Walker_B" amino acids 908 to 975 (68 residues), 34.8 bits, see alignment 1.6e-12

Best Hits

KEGG orthology group: K03546, exonuclease SbcC (inferred from 100% identity to slo:Shew_2456)

Predicted SEED Role

"Exonuclease SbcC" in subsystem DNA repair, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QFS4 at UniProt or InterPro

Protein Sequence (1018 amino acids)

>Shew_2456 SMC domain-containing protein (RefSeq) (Shewanella loihica PV-4)
MRPLRLTMTAFGPFADEQIIDFAALGSNPLFLINGPTGAGKTTILDAICFALYGKTTGDE
REGTQMRCDMADEQRLTQVSFEFELGSTRYLIRRVPEQPRAKKSGEGVTLQKSEAQLSRV
DTDGSETLLVAAKVSDATAQIEQLTGLDVDQFRQVMVLPQGKFRELLMADSKAREKIFSQ
LFQTHIYRRIEERLKQQAAGIRRDVEAMRNRRGGILEGAELASDQALIEEQALIAPELEL
AQAHKQQAEQALLTANQNLDKGLKLQSDFNRLQALQSEGEGLKARQLEATLWQQRLQAAG
RANSLSPLYRAMQSRLGEQRSASQHLDECQQIHASAEQALNQSQQAFEQLGALEQEQLSQ
QQRLTQLEALAPQLEQLNQLSERLADGQAKMQAAEASGKQSAKQLDELNQARQEIVSRRE
ILKRDAEPQLALQQSLSDGRAQLKVFERWQQQGLEIAALEQKLTAAKTAGSELAEKHKQA
IDAHKRLELSWHRGQAARLAAELSPGEPCPVCGSLEHPEPAMGEFDLPSDEALAQAKQRE
SDALNLLHQARSEYKLLQQSLSNLQLSASLLQEELGEAAGLSFDEHQARLAELSDGFERA
KAAQQSLAQLETQLERSEHQGRELQTALDEARAHYGKLAEQLASDKGQYQQISAAIPQGF
SDVATLSTAIADLTKTIDELKARQQSVRAAHAKAEQDNAAAKASLEAASRRLGEVNALAE
QESLSFQQALATSEFESVAAFEQACLTEAEQAELSNQIKAFEQALITHQANLSQLQEALA
GCEAPDMSALEQQKMDAEQVMQQALAQWQKVSARAAQLSQTQEQLKALDLKAGALEQQYA
VVGTLADVANGNTGNKISLQRFVLSVLLDDVLLEASHRLQLMSKGRYRLLRKEERAKGNK
ASGLELEVEDAYTAKVRSVATLSGGESFMAALSMALGLSDVVQAYAGGIKLDTLFIDEGF
GSLDQDSLELAIRTLMDLQSAGRMVGVISHVTEMKEQIASRIDILKSAEGSEIKLVLP