Protein Info for Shew_2435 in Shewanella loihica PV-4

Annotation: sodium/proline symporter (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 483 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 46 to 70 (25 residues), see Phobius details amino acids 76 to 93 (18 residues), see Phobius details amino acids 124 to 149 (26 residues), see Phobius details amino acids 162 to 183 (22 residues), see Phobius details amino acids 188 to 208 (21 residues), see Phobius details amino acids 229 to 247 (19 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 314 to 340 (27 residues), see Phobius details amino acids 364 to 382 (19 residues), see Phobius details amino acids 394 to 413 (20 residues), see Phobius details amino acids 420 to 436 (17 residues), see Phobius details amino acids 448 to 467 (20 residues), see Phobius details TIGR02121: sodium/proline symporter" amino acids 6 to 481 (476 residues), 681 bits, see alignment E=9.2e-209 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 35 to 428 (394 residues), 327.5 bits, see alignment E=1.3e-101 PF00474: SSF" amino acids 35 to 428 (394 residues), 354.2 bits, see alignment E=4.8e-110

Best Hits

Swiss-Prot: 52% identical to PUTP_BACSU: High-affinity proline transporter PutP (putP) from Bacillus subtilis (strain 168)

KEGG orthology group: K11928, sodium/proline symporter (inferred from 100% identity to slo:Shew_2435)

Predicted SEED Role

"Proline/sodium symporter PutP (TC 2.A.21.2.1) @ Propionate/sodium symporter" (TC 2.A.21.2.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QFQ3 at UniProt or InterPro

Protein Sequence (483 amino acids)

>Shew_2435 sodium/proline symporter (RefSeq) (Shewanella loihica PV-4)
MNIELPILVTFFGYLILMMGIGLWAYKATDSVDDYILGGRSMGPAVTALSVGASDMSGWL
LLGLPGAVYLGGLGEAWIGIGLVFGAWLNWLFVAKRLRIYTQFTDNALTLPDFFEKRFED
KQSVLKLVSAVTILVFFTFYTSSGMVGGAILFEKVFGLDYNLALLIGSGIIVAYTFVGGF
FAVSWTDFFQGCLMLIALLIVPVTIFSQPETQNGIHSLDPAMLSLLSDNTTMIGLASLLA
WGLGYFGQPHILSRFMAIGSADDLKVSRRIAMSWMIVALMGALATGLAGTLYFADQPIDN
PETIFIHLAHAAFNPWIGGLLVAAILSAIMSTIDSQLLVCSSVITEDFYKKWLRPDASSK
ELMMIGRIGVLTIAVISGVIALNPESSVLSLVSYAWAGFGAAFGPVVILSLFWRGYSRNG
AVATIIVGAITVVLWKQSTGGIFDLYEILPGFLFATLAGVLVSLVSAPADSTREQFEQFS
QKL