Protein Info for Shew_2431 in Shewanella loihica PV-4

Annotation: TPR repeat-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 693 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 56 to 76 (21 residues), see Phobius details amino acids 305 to 332 (28 residues), see Phobius details PF13519: VWA_2" amino acids 91 to 197 (107 residues), 59.3 bits, see alignment E=1.4e-19 PF07719: TPR_2" amino acids 399 to 430 (32 residues), 30 bits, see alignment (E = 8.8e-11) PF13176: TPR_7" amino acids 401 to 430 (30 residues), 16.7 bits, see alignment (E = 1.5e-06)

Best Hits

KEGG orthology group: K07114, uncharacterized protein (inferred from 88% identity to slo:Shew_2431)

Predicted SEED Role

"TPR domain protein in aerotolerance operon"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QFP9 at UniProt or InterPro

Protein Sequence (693 amino acids)

>Shew_2431 TPR repeat-containing protein (RefSeq) (Shewanella loihica PV-4)
MIHFLRPEWLLALIPLALLLWLRKRQRHQASSWNRYIAPHLAKVLVSGQASNKKQHLGLI
AFIWLVSVLALSGPALTKQQLPVFEANLGRVIVMDMSLSMYATDLAPNRLTQAKFKATDL
IKSLKEGETGLVAYAGDAFTISPLTRDKSTLLNLLPTLSPEIMPVLGSNLPAALDQAKQL
LVQGGHLKGEIILLADGVNPDQIGEAKSILDDTQYRLSIIAMGTNQGAAIRLPDGQLMRD
QSDQVVVSQTDLSQLNSLIGNSGGKLFAYRADGKDLESLTQSLSQESDAKTSDRQGEAWQ
DLGPYLALLLLLPALLSFRHAFAALACLVILAPSPEAQAASWQHPFSTDDQRAMQAYQAQ
DFQGAAEQFTSPQWKAASLYKNGDYQEALKLFEQDDSASGLFNQGNSLMQLNDLDKAIER
YQQALKKDPQLTQAEQNLELAEQLKQQQQASQDQGQSDQKKSEQNQSDQDQSNQDSNKQD
KSQQDGAGQNQGQQQGQGDQQSGQGSRGQQSQGQNGQQEDEQGSNQQGSDKQGSDKQSAS
QESPEQETPEQQASAEQEASQDGQSQNQQTGAANDAQMSADPAKDAKNQMDANANQSDAG
QQMGQGQQPQDEQESTQAQAANMTQGKPGEGDEQGEPVAAATNAIAPEDLPPEMQRALTG
VIDDPQVLLRNKMQLEYQKRRRQGATIKDNQQW