Protein Info for Shew_2363 in Shewanella loihica PV-4

Annotation: proline racemase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05544: Pro_racemase
  • amino acids 8 to 331 (324 residues), 418.1 bits, E=1.2e-129

Best Hits

Swiss-Prot: 100% identical to 4HYPE_SHELP: 4-hydroxyproline 2-epimerase (Shew_2363) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2363)

Predicted SEED Role

"4-hydroxyproline epimerase (EC 5.1.1.8)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 5.1.1.8)

MetaCyc Pathways

• trans-4-hydroxy-L-proline degradation II (3/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.1.8

Sequence Analysis Tools

See A3QFI1 at UniProt or InterPro

Protein Sequence (333 amino acids)

>Shew_2363 proline racemase (RefSeq) (Shewanella loihica PV-4)
MLKGTFFCVDAHTCGNPVRLVTSGHPDLKGRTMSEKRQDFLAQYDWIRKALMFEPRGHDM
MSGAFLYPPCSDNADAAILFIETSGCLPMCGHGTIGTITAALESGLLTPKMPGQLTIDVP
AGQIKVQYQQTGAKVDWVKIFNVPAYLAHKDVVLDIPGLGPLKIDVSYGGNYYAIVDPQA
NFPGLRHWSAGDILRWSPIVREVAHRELNCVHPDDPTVNGVSHVLWTGDTISEGSNGANA
VFYGDKAIDRSPCGTGTSARLAQLYSRGELKVGDEYTHESIIGSQFVGRIEAATKVGAFD
AIMPSIKGWARITGHNAITVDDNDPYAFGFQVV