Protein Info for Shew_2265 in Shewanella loihica PV-4

Annotation: aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 747 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 11 to 37 (27 residues), 16.7 bits, see alignment (E = 3.6e-07) PF20256: MoCoBD_2" amino acids 23 to 181 (159 residues), 59.1 bits, see alignment E=5.3e-20 amino acids 612 to 696 (85 residues), 55.5 bits, see alignment E=6.6e-19 PF02738: MoCoBD_1" amino acids 333 to 546 (214 residues), 95 bits, see alignment E=4e-31

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 100% identity to slo:Shew_2265)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QF83 at UniProt or InterPro

Protein Sequence (747 amino acids)

>Shew_2265 aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding (RefSeq) (Shewanella loihica PV-4)
MSQFSAVQNFSRRDVLKLFGAAGGGLALGASGLAWSPMALAQNGEARLNLFIAIGEDDRV
YLTCHRSEMGQGIRTGIPQVLADELGADWDKVVVVQGLADKRYGSQNTDGSRSIRKGFDK
MREMGAMARTMLEQAAAERLKVPVAELSTADNKVTHSASGRSLSFGELAMAAAKLPLPEV
TGLKLKSAKAFTHIGKGHTIVDMEAILDGSAEYGYDIHLENMLYASIVRPPVLGSKVDKL
DDKAARAVAGVVDVIPLPGHQGAPSFQPLGGVAVLATNSWSAAQGRKALKVSWSDSPNDG
HDSSAYLAQLKRAVQKSGKPVRQLGEQSQSWPADKTIEAVYSVPYLAHAMMEPPAAAASV
TDKTAEIWASTQTPQSAQGTVAAALGLQAEQVTVHVTLLGGGFGRKSKPDFCVEAALLSQ
KTGRPVKVCWSREDELQNGYLHAISAQYFKARVGDKAVEAILQRTGFPSISSTFAEGVDE
PSASELDLGFVDVPLAIDSLRCESVKASAHTRIGWMRSVCNIQHGFGIGVFVDELANKRG
LDTYTMWRELLGKDRQETFSDQQFNYGNYGETLERHPVDTARYKGVISAVEQEVKQMAKP
EAGQGWGFAVHRSFTAYVAAASLVEVTQDKQLKVLKTVIAIDAGTLVNPDRVASQLEGAV
MFGLSIALMGRISFKDGRVEQSNFHDYPLLRMSQCPEIETILVPSMAPPAGVGEPGVPPI
APSIVNAIYAASGTRIRDLPLSDHFKI