Protein Info for Shew_2207 in Shewanella loihica PV-4

Annotation: integral membrane sensor signal transduction histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 760 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 490 to 507 (18 residues), see Phobius details PF17874: TPR_MalT" amino acids 63 to 205 (143 residues), 32.5 bits, see alignment E=2.6e-11 PF13424: TPR_12" amino acids 132 to 202 (71 residues), 43 bits, see alignment E=1.9e-14 amino acids 169 to 242 (74 residues), 50.3 bits, see alignment E=1e-16 amino acids 209 to 281 (73 residues), 48 bits, see alignment E=5.3e-16 amino acids 289 to 354 (66 residues), 32.4 bits, see alignment E=3.9e-11 PF13181: TPR_8" amino acids 133 to 162 (30 residues), 13.8 bits, see alignment (E = 2.6e-05) amino acids 250 to 279 (30 residues), 15.8 bits, see alignment (E = 5.9e-06) PF13374: TPR_10" amino acids 170 to 203 (34 residues), 17.1 bits, see alignment (E = 2.1e-06) amino acids 210 to 243 (34 residues), 23.8 bits, see alignment (E = 1.6e-08) PF00512: HisKA" amino acids 526 to 589 (64 residues), 41.3 bits, see alignment E=5.9e-14 PF02518: HATPase_c" amino acids 636 to 743 (108 residues), 80.5 bits, see alignment E=5.7e-26

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2207)

Predicted SEED Role

"Sensor protein rstB (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QF25 at UniProt or InterPro

Protein Sequence (760 amino acids)

>Shew_2207 integral membrane sensor signal transduction histidine kinase (RefSeq) (Shewanella loihica PV-4)
MRKKPIALLLLAILISLSLVGITARMDPPEARADITEREAQLTTLPENQQGELLTALVKH
YRDNDPLKSLAYGEQALTLFSKIPDDIRKVTVLNNMAWIYVSLSQYENAQLRTDQAKQLA
KASNDPHGLFTAQTMQGIIYWRKADYQTALKTFEQAQEIAKQEKNLRGIASTTNYMAIIY
QTLGQPEKALDYFIRAFNIQKEVGDEKSIAVSLNNIANMYGTSGNYSLALDYQLQSRKIR
EELNDLPGLAQILGNIGLTYFYLKDSEQALSYLQRSLGYYESLKDQQGIAEIHGNLGMVH
LHEHQLESALLQYQEALALAKAIPDTALEARINIDLANAYIELDDPEQAFKQITTGLDQA
NKLGIVSLSAYGLLTLAKVEKLRGNSERALTLSAAALNSSQQLQDKRIVRDAHEFRYQLY
KHLGQAEQALASLEAFKQVNDEMFNSESDQRMAFLLSHFEAEQQEQQIKLLQADQALQKT
QLAQHTYQRNVWLGGLSVLFIILLLLVNRHHQRKINASLNQNIQSQRELIQAVAHEFRSP
LARVQLAFDMLEEQFEQDKPTRLIDTINKGLSELEKLIKEALDFIQIESKSRPLHLSQVN
LNKLLGELMDANSVLYPDKTFKLEVNPSEACLVKADSTQIARAFSNILRNAARFARSQVL
ISLKQEKSRILVIIEDDGPGIPTEQRERVFEPFVRLDQSRCRDSGGIGLGLALAKKICEA
HGGALTISASQLGGAKLSLACPLVNRESDNKNSSTKAAEH