Protein Info for Shew_2197 in Shewanella loihica PV-4

Name: hisG
Annotation: ATP phosphoribosyltransferase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 299 TIGR00070: ATP phosphoribosyltransferase" amino acids 7 to 197 (191 residues), 185.5 bits, see alignment E=9.1e-59 PF01634: HisG" amino acids 54 to 218 (165 residues), 166.1 bits, see alignment E=6.2e-53 TIGR03455: ATP phosphoribosyltransferase, C-terminal domain" amino acids 201 to 298 (98 residues), 96.5 bits, see alignment E=8.8e-32 PF08029: HisG_C" amino acids 223 to 296 (74 residues), 79 bits, see alignment E=2.3e-26

Best Hits

Swiss-Prot: 100% identical to HIS1_SHELP: ATP phosphoribosyltransferase (hisG) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: K00765, ATP phosphoribosyltransferase [EC: 2.4.2.17] (inferred from 100% identity to slo:Shew_2197)

MetaCyc: 68% identical to ATP phosphoribosyltransferase (Escherichia coli K-12 substr. MG1655)
ATP phosphoribosyltransferase. [EC: 2.4.2.17]

Predicted SEED Role

"ATP phosphoribosyltransferase (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QF15 at UniProt or InterPro

Protein Sequence (299 amino acids)

>Shew_2197 ATP phosphoribosyltransferase (RefSeq) (Shewanella loihica PV-4)
MSESNRLRIAIQKSGRLSKESQKLLKSCGIKFNVNEQRLIAHSDNMPIDLLRVRDDDIPG
LVMDGVVDLGIIGENVLEEEQIERQTLDKPSECIKLRQLDFGACRLSLAVPTEFRYQDAS
SLEGLRIATSYPNLLRRYMQEKGISYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEAN
GLYETEVIYRSMACIIQSTQEQSEAKQALIDKILSRVNGVVRAKESKYILLHAPTETLDQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSSEDLFWDTMEALTQLGASSILVMPIEKMMG