Protein Info for Shew_2161 in Shewanella loihica PV-4

Annotation: peptidyl-dipeptidase Dcp (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF01432: Peptidase_M3" amino acids 274 to 722 (449 residues), 438.2 bits, see alignment E=2.8e-135

Best Hits

Swiss-Prot: 41% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 100% identity to slo:Shew_2161)

MetaCyc: 41% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

Compare fitness of predicted isozymes for: 3.4.15.5

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QEX9 at UniProt or InterPro

Protein Sequence (726 amino acids)

>Shew_2161 peptidyl-dipeptidase Dcp (RefSeq) (Shewanella loihica PV-4)
MKGLTLKPIVSAMALAIALGGCSAQQGSSQQAEVAPNAVAQRIIDNNASNPFFKPYDTFL
GMPDFDKIKPEHYLPAFKAGIAQHKAEIQAIIDNPAAPTFANTIEAMEFAGDLTTKVASV
FYNLTSADTNEQLQAISKEVSPMLSAAGDDILLNDQLFKRVKAVYDQRDSLALNTAQQKL
LEDTYKSFTRGGANLSDADKVKLRALNEKIGKLSLEFGDNLLAETNAFELVIDNAADLKG
LPQDVINTAAQTAEKKGHPGKWVFTTQRPSITPFLTYADNRELREKIYKGYVERGNNNNA
HDNKKILAQMAALRAERAQLMGYKSHAHFVLEERTAKTPENVYGLLDKVWPAALGQAKAE
VAVMQELIDAEGGNFKLAAWDWWYYADKIRVAKYSFNEQETRPYFSLENTLKGVFYTANR
LYGITVKERTDLPKYNDEVRTWEVYDKDGSLMAIFLGDYYVRDSKRGGAWANAYRKQYRM
HGVESKPIIVNVLNYPRPVGDEPALLTFDEASTLFHEFGHALHAMLSDVEYRSQAGTSVP
RDYVEFPSQVMENWMTQPEVLAQFAKHYKTGEVIPQSLVEKIQAASKFNQGFATVEYMAA
TKLDLDWHTLSDFEPKDAAKFEADSLSKMGLIEEIAPRYRSTYFSHIFSGGYSAGYYSYL
WSDILGADAFEAFKENGIFDKATADAFRNNVLSQGGSEDPMLLYKQFRGKEAGIEPLLRS
RGLLAK