Protein Info for Shew_2047 in Shewanella loihica PV-4

Annotation: 6-phosphogluconolactonase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01198: 6-phosphogluconolactonase
  • amino acids 10 to 224 (215 residues), 185.2 bits, E=6.9e-59
• PF01182: Glucosamine_iso
  • amino acids 12 to 222 (211 residues), 191.2 bits, E=1.2e-60

Best Hits

Swiss-Prot: 40% identical to 6PGL_PSEAE: 6-phosphogluconolactonase (pgl) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01057, 6-phosphogluconolactonase [EC: 3.1.1.31] (inferred from 100% identity to slo:Shew_2047)

Predicted SEED Role

"6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type" in subsystem Entner-Doudoroff Pathway or Pentose phosphate pathway (EC 3.1.1.31)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (15/17 steps found)
• pentose phosphate pathway (8/8 steps found)
• heterolactic fermentation (15/18 steps found)
• superpathway of glucose and xylose degradation (14/17 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)
• formaldehyde oxidation I (3/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.31

Sequence Analysis Tools

See A3QEL5 at UniProt or InterPro

Protein Sequence (232 amino acids)

>Shew_2047 6-phosphogluconolactonase (RefSeq) (Shewanella loihica PV-4)
MIKESVFKSFDSKTSLEAQLADRIAEQLQAAIDARGKASLVVSGGSTPLALFKLLSQKAI
EWNDVYITLADERWVDSEHSDSNERLVRQHLLQNRAAGAKFRGLKNMFATPEAGVDMAIE
QLANFPRPFDVVVLGMGNDGHTCSWFPCAKEIEQALTTQALCLAVNPGEAPHGRMTISKQ
GILASRQIYLHIVGEQKLAVYRQALENDDAKAMPIRAVLAQHKTPVDVYWSA