Protein Info for Shew_1818 in Shewanella loihica PV-4

Annotation: ATP-dependent protease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 PF20436: LonB_AAA-LID" amino acids 242 to 299 (58 residues), 25.3 bits, see alignment 1.2e-09 PF05362: Lon_C" amino acids 412 to 517 (106 residues), 40.6 bits, see alignment E=2.2e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_1818)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QDY6 at UniProt or InterPro

Protein Sequence (569 amino acids)

>Shew_1818 ATP-dependent protease (RefSeq) (Shewanella loihica PV-4)
MIAHSIDAAALSPQFNLPKVDQLKPNLHSRLLGQERTLDAFNLLAKACGQHMYLADQSGI
DRLALISALVDYQGHRATHYLNRLAPDASLAWQTEAGDECLCSASKPYRYLSGAIRRRDL
IGHLDAHNPNVYHPGAMADCDYLFICAESLWKREALWELVMEAAHLGEYQLHSGWPAIPL
HSKIILVGSSTLYSVSYLEERNFPAAFSLLGELVDEIDLNEFSELDYGNYLVELAEANQL
TLEQSALAPLFNYSSRLAEHQRHLSLETLGISQLMVQAALYGKSKQLNGENIAIALARHK
TRHNASQSLSAQSFDDNFINLPTQGAMIGQINGLTVLDAAEYTYGEPARITAAVHYGDGE
VADIERKSELGGNIHAKGLMILTSCLYRIFGKDAPLHLNANIVFEQSYQEIDGDSASLAE
YCALMSAIAEQPIEQGIAATGAIDQFGQVQAIGGVNEKIEGFFDLCQRRGLTGTQGVIIP
ASNVQQLNLAPAVIAAVKAKEFHLYQVEHTDQAVAILMNKPAGSRDDNGQFPEESLYGMV
QARLEGLAGYPDEERSFFANLLHKLKLSS