Protein Info for Shew_1758 in Shewanella loihica PV-4

Annotation: hydrogenase assembly chaperone hypC/hupF (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 82 TIGR00074: hydrogenase assembly chaperone HypC/HupF" amino acids 1 to 80 (80 residues), 71.9 bits, see alignment E=1.6e-24 PF01455: HupF_HypC" amino acids 1 to 68 (68 residues), 73.7 bits, see alignment E=5.4e-25

Best Hits

Swiss-Prot: 47% identical to HYPC_HELHP: Hydrogenase maturation factor HypC (hypC) from Helicobacter hepaticus (strain ATCC 51449 / 3B1)

KEGG orthology group: K04653, hydrogenase expression/formation protein HypC (inferred from 100% identity to slo:Shew_1758)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypC" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QDS6 at UniProt or InterPro

Protein Sequence (82 amino acids)

>Shew_1758 hydrogenase assembly chaperone hypC/hupF (RefSeq) (Shewanella loihica PV-4)
MCLSIPSRIVALHPEEQAVTVETLGVKRKVSSHLMEEPLALDDYVLIHIGFVMNKIDKAD
AEQSLALYQEIVAKMNEQETQA