Protein Info for Shew_1234 in Shewanella loihica PV-4

Annotation: peptidase S41 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1104 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF07676: PD40" amino acids 73 to 108 (36 residues), 14.5 bits, see alignment (E = 8.4e-06) amino acids 497 to 523 (27 residues), 25 bits, see alignment (E = 4.2e-09) PF14684: Tricorn_C1" amino acids 701 to 759 (59 residues), 74.4 bits, see alignment 1.6e-24 PF14685: PDZ_Tricorn" amino acids 785 to 868 (84 residues), 55.8 bits, see alignment 1.1e-18 PF17820: PDZ_6" amino acids 823 to 860 (38 residues), 35.9 bits, see alignment (E = 1.6e-12) PF03572: Peptidase_S41" amino acids 901 to 1055 (155 residues), 104 bits, see alignment E=2e-33

Best Hits

KEGG orthology group: K08676, tricorn protease [EC: 3.4.21.-] (inferred from 100% identity to slo:Shew_1234)

Predicted SEED Role

"Tricorn protease homolog (EC 3.4.21.-)" (EC 3.4.21.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QCA6 at UniProt or InterPro

Protein Sequence (1104 amino acids)

>Shew_1234 peptidase S41 (RefSeq) (Shewanella loihica PV-4)
MKLSHLFACCAIALGTASSAPLFAAQAENVKAESQATEQNVGYYRSPAIHGDTLVFTAEG
DLWIQQLGDAQARRLTSLPAQELGAAISNDGQQLAFVANYEGASEVYVMPIQGGVAKRVS
FENSRVRVQGWTPDGKVLYATDNAFGPANYWVLRSVDPESLTTQDLPLADAIEGVVDNAG
EYVYFTRFGLQATGDNAKVYRGGAKGELWRYKLGSDQEAQPLTAEHDGSVRQPMLWQDRL
YFVSDSSGNDNIWSMTLDGKDLRQLTQFSDWQVRGARLEQGRVVFQQGADIKLYDIASNQ
VSTLDIHLTSDFPERREHWVNKPMKYATSTSLAPNGDKVVITARSHVALAGTDGSRLVEL
GLPGDYRVRGAVMSPDGKWVYGISDASGEQEIWRYSADGSDEAKQLTQDGKALRMALSLS
PDGRYIAHDDYNGDLWLLDLKKGRNSKILTNGQGLGPYGDVVWSNDSRFIAVTKDERGQL
RPQIVLYSLEEERAEALTSDKYESFSPAFSDDGQWLYFISNREFNATPTSPWGDRNMGPV
FDKRGQIFALALTPKAVFPFSKPNELNQPAAKEEEAAKKPAKTQVQWQGLSKRLWQVPVA
SGNYSQLQVTEKGLYMLANSVDRAQAPNLMWVKFDPLGPKVETFSEDVASYALSGDDSKL
FLRRHSKGGAEMLIVDTGESLPKDLAHAKVQTEQWQLAISPQLEWQQMFEDAWLMHRDSF
FDKKMRGLDWQATKAKYQPLLARLTDRHELNDIFMQMMGELDALHSQVRGGDLPLDPNQP
QGANLGARLLQTKQGVQIAHIYQNDAELPQQASPLARVDVDAKVGDIILAINGKPVENVA
DVARHLRNQADKQVLLTLKRDRNSFKTIVLPVANRADAKLRYLDWVNNNNQKVAKAADGE
IGYLHLYAMGSGDIANFAREFYANIEKKGLIIDVRRNRGGNIDSWIIEKLLRRAWMFWQP
TQGTPNTNMQQTFRGHLVVLTDQLTYSDGETFSAGIKALGLAPLIGKQTAGAGVWLSGRN
SLTDKGMARVAEYPQYAMDGRWIVEGRGISPDIEVDNLPHATFKGEDAQLNKALNYLKQK
LELEPVLPIKAQPMPSSGMAQDVK