Protein Info for Shew_1181 in Shewanella loihica PV-4

Annotation: PepSY-associated TM helix domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 376 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 135 to 157 (23 residues), see Phobius details amino acids 184 to 205 (22 residues), see Phobius details amino acids 321 to 345 (25 residues), see Phobius details PF03929: PepSY_TM" amino acids 6 to 348 (343 residues), 200.1 bits, see alignment E=3.8e-63

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_1181)

Predicted SEED Role

"Uncharacterized iron-regulated membrane protein; Iron-uptake factor PiuB"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QC53 at UniProt or InterPro

Protein Sequence (376 amino acids)

>Shew_1181 PepSY-associated TM helix domain-containing protein (RefSeq) (Shewanella loihica PV-4)
MRRLLWKWHGWLGLFAALPLFIIALTGSVLVFKSELEHLLMPEKVLAASETRLSFTQLLR
SADEALPQHEILGWQFAPNAGEADKLYVAKQGTYDWQLLFVDPSQGSLLSQPVGLSHYLL
DWLLELHYTLLADHLGLAVTALVSILLILLSLSGFILHRQFWRTFFTLRWGKSLRLFLSD
SHKMLGIIGAPLFLILGFTGAWWNIEHIIEEWHEPDPKTLIVTQSYYNKQLDVEALLTQA
TQVIPGFQTHYVRFPDKSYAGIHLFGAAQDRGALRSDYGSIVSFDDKSGQLSASVDATKA
GALYQFVDSFRPLHYGNFGGLVSKIIWCVVGFLPSLMALSGYLMWRARRKPQTRRRAKQT
IESPSNRDAKEGLAKA