Protein Info for Shew_1135 in Shewanella loihica PV-4

Annotation: protein of unknown function YGGT (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 182 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 61 to 86 (26 residues), see Phobius details amino acids 91 to 115 (25 residues), see Phobius details amino acids 153 to 172 (20 residues), see Phobius details PF02325: CCB3_YggT" amino acids 1 to 82 (82 residues), 76.6 bits, see alignment E=7.5e-26 amino acids 97 to 175 (79 residues), 78.2 bits, see alignment E=2.4e-26

Best Hits

Swiss-Prot: 38% identical to Y392_PSEAE: Uncharacterized protein PA0392 (PA0392) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02221, YggT family protein (inferred from 100% identity to slo:Shew_1135)

Predicted SEED Role

"Integral membrane protein YggT, involved in response to extracytoplasmic stress (osmotic shock)" in subsystem Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QC08 at UniProt or InterPro

Protein Sequence (182 amino acids)

>Shew_1135 protein of unknown function YGGT (RefSeq) (Shewanella loihica PV-4)
MDALSFLVNTLFDLYLMVVIIRIWLQLARADFYNPFSQFVVKATHPVVGPMRRFLPPLGG
LDTASVVLALAVVVIKFVILSLMAGAAINLPIILLVALVSVLKQAGVLLFWMLILRAILS
WVSQGHNPIEMVMAQLTEPLVAPIRRIIPPMGGLDFSVMIFMFGLIFINKLLSQYVPFWA
NV