Protein Info for Shew_1097 in Shewanella loihica PV-4

Annotation: integral membrane protein MviN (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 519 signal peptide" amino acids 5 to 20 (16 residues), see Phobius details amino acids 24 to 24 (1 residues), see Phobius details transmembrane" amino acids 21 to 23 (3 residues), see Phobius details amino acids 28 to 46 (19 residues), see Phobius details amino acids 92 to 122 (31 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 166 to 188 (23 residues), see Phobius details amino acids 198 to 218 (21 residues), see Phobius details amino acids 245 to 249 (5 residues), see Phobius details amino acids 254 to 275 (22 residues), see Phobius details amino acids 282 to 301 (20 residues), see Phobius details amino acids 322 to 346 (25 residues), see Phobius details amino acids 359 to 380 (22 residues), see Phobius details amino acids 392 to 412 (21 residues), see Phobius details amino acids 418 to 438 (21 residues), see Phobius details amino acids 450 to 472 (23 residues), see Phobius details amino acids 490 to 510 (21 residues), see Phobius details TIGR01695: murein biosynthesis integral membrane protein MurJ" amino acids 4 to 511 (508 residues), 465.2 bits, see alignment E=1.4e-143 PF03023: MurJ" amino acids 30 to 483 (454 residues), 485 bits, see alignment E=2e-149 PF14667: Polysacc_synt_C" amino acids 369 to 509 (141 residues), 55 bits, see alignment E=1.1e-18

Best Hits

Swiss-Prot: 70% identical to MURJ_VIBCH: Probable lipid II flippase MurJ (murJ) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03980, virulence factor (inferred from 100% identity to slo:Shew_1097)

Predicted SEED Role

"Proposed peptidoglycan lipid II flippase MurJ" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QBX0 at UniProt or InterPro

Protein Sequence (519 amino acids)

>Shew_1097 integral membrane protein MviN (RefSeq) (Shewanella loihica PV-4)
MSKKLFKSGMIVSAMTLISRVLGLVRDVVIANLMGAGSSADVFFFANKIPNFLRRLFAEG
AFAQAFVPVLTEYQEKHDDQAVRELLAKVAGTLGLVVTLVTLMGVIASPLLTALFGGGWF
LAWLNDEPNGQKFELASLMLKITFPYLWFITFTALAGSILNTRGRFAVSAFTPVFLNVAI
ISAALFLAPKLDQPEIGLAWGVFAGGLIQFLFQIPFLFREKALVKPSWGWHHPGVVKIRT
LMLPALFGVSVSQINLLLDTFIASFLVTGSISWLYYSDRLLEFPLGLFGIAIATVILPAL
SKKHVNAEGDGFAKTMDWGIKAILLMGVPAMCGLIVLAKPMLMVLFMRGAFTLDDVDMAS
YSLMAYGSGLLSFMLIKVLAPGYYSRQDTKTPVRYGIVAMVSNMVFNLIFVFPFGYVGLA
IATSLSALLNASLLYRGLHRAGVYQIPRQTFVFMGKTLVAAALMIAVLYLLLPSIDTWLA
LSFMGRATQLAYLIGAGAVVYLLAMLLLGIRPWRMKAGF